Laparoscopic versus open left hemihepatectomy for hepatocellular carcinoma: a propensity score matching analysis
Despite the increasing application of laparoscopic hepatectomy (LH) for hepatocellular carcinoma (HCC), laparoscopic left hemihepatectomy (LLH) remains a relatively rare surgery and comparison of perioperative and oncological outcomes between LLH and open left hemihepatectomy (OLH) is lacking. A tot...
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Published in | Translational cancer research Vol. 9; no. 9; pp. 5484 - 5492 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
China
AME Publishing Company
01.09.2020
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Subjects | |
Online Access | Get full text |
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Summary: | Despite the increasing application of laparoscopic hepatectomy (LH) for hepatocellular carcinoma (HCC), laparoscopic left hemihepatectomy (LLH) remains a relatively rare surgery and comparison of perioperative and oncological outcomes between LLH and open left hemihepatectomy (OLH) is lacking.
A total of 276 HCC patients who underwent either LLH or OLH between January 2008 and November 2019 were enrolled in this retrospective observational study and a 1:2 propensity score matching (PSM) was performed between LLH and OLH groups.
Patients in LLH group had smaller tumor size (P=0.001) and earlier TNM staging (P=0.022) before matching. Despite the similar transfusion rate after matching, patients undergoing LLH (n=27) experienced less intraoperative blood loss (100.0 versus 200.0 mL; P=0.034) and application of hepatic portal occlusion (11.1% versus 63.5%; P<0.001) compared to those in OLH group (n=52). There were no statistical differences of resection margin and incidence of complications between the groups. The overall survival (OS) and disease-free survival (DFS) of patients in LLH group were comparable to OLH group (3-year OS rate: 75.0% versus 84.9%; 1-year DFS rate: 92.3% versus 92.2%).
LLH may be a feasible and safe alternative to OLH for selected HCC cases, providing potential short-term benefits without compromising oncologic adequacy and prognosis. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work. Contributions: (I) Conception and design: N Ren; Y Yi; (II) Administrative support: N Ren; (III) Provision of study materials or patients: Y Yi; C Zhou; (IV) Collection and assembly of data: J Weng; G Liu; (V) Data analysis and interpretation: J Weng; C Zhou; (VI) Manuscript writing: All authors; (VII) Final approval of manuscript: All authors. |
ISSN: | 2218-676X 2219-6803 |
DOI: | 10.21037/tcr-20-1573 |