Analysis of whole blood for drugs of abuse using EMIT d.a.u. reagents and a Monarch 1000 Chemistry Analyzer

This paper describes refinements in procedures coupling methanolic extraction-precipitation of whole blood with subsequent screening for commonly encountered drugs of abuse using EMIT d.a.u. reagents on a Monarch Chemistry Analyzer. The automation capabilities inherent in the Monarch make batch proc...

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Bibliographic Details
Published inJournal of analytical toxicology Vol. 17; no. 3; p. 133
Main Authors Diosi, D T, Harvey, D C
Format Journal Article
LanguageEnglish
Published England 01.05.1993
Subjects
Autoanalysis
Enzyme Multiplied Immunoassay Technique
Freezing
Gas Chromatography-Mass Spectrometry
Humans
Indicators and Reagents
Solvents
Substance Abuse Detection - instrumentation
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Summary:This paper describes refinements in procedures coupling methanolic extraction-precipitation of whole blood with subsequent screening for commonly encountered drugs of abuse using EMIT d.a.u. reagents on a Monarch Chemistry Analyzer. The automation capabilities inherent in the Monarch make batch processing of samples convenient and cost effective. The small sample volume requirement of the Monarch allows greater sensitivities and use of lower cutoffs than previously reported. Subsequent analysis of EMIT positives by GC/MS confirmed the presence of the indicated drugs of abuse 86.7% of the time.
ISSN:0146-4760
DOI:10.1093/jat/17.3.133