Carotid atherosclerosis and serum lipoprotein(a) concentrations in patients with NIDDM

• Published in: Diabetes care Vol. 20; no. 5; pp. 829 - 831
• Main Authors: YAMAMOTO, M, EGUSA, G, YAMAKIDO, M
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.05.1997
• Subjects: Apolipoprotein A-I - blood; Apolipoproteins B - blood; Arteriosclerosis - blood; Arteriosclerosis - diagnostic imaging; Arteriosclerosis - physiopathology; Associated diseases and complications; Atherosclerosis; Biological and medical sciences; Blood Pressure; Cardiovascular disease; Carotid Arteries - diagnostic imaging; Carotid Artery Diseases - blood; Carotid Artery Diseases - diagnostic imaging; Carotid Artery Diseases - physiopathology; Cerebrovascular disease; Cholesterol; Coronary Disease - epidemiology; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Diabetic Angiopathies - blood; Diabetic Angiopathies - diagnostic imaging; Diabetic Angiopathies - physiopathology; Diabetic Nephropathies - epidemiology; Diabetic nephropathy; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Female; Humans; Ischemia; Lipids; Lipoprotein(a) - blood; Lipoproteins; Male; Medical sciences; Metabolism; Middle Aged; Myocardial Ischemia - epidemiology; Prevalence; Research design; Risk factors; Statistical significance; Tunica Intima - diagnostic imaging; Tunica Media - diagnostic imaging; Ultrasonography; Endocrinopathy; Human; Pathogenesis; Cardiovascular disease; Exploration; Concentration; Metabolism; Non insulin dependent diabetes; Lipoprotein a; Blood plasma; Vascular disease; Assay; Association; Carotid; Atherosclerosis; Clinical biology; Risk factor
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/diacare.20.5.829

Carotid atherosclerosis and serum lipoprotein(a) concentrations in patients with NIDDM. M Yamamoto , G Egusa and M Yamakido Second Department of Internal Medicine, Hiroshima University School of Medicine, Japan. maki@mcai.med.hiroshima-u.ac.jp Abstract OBJECTIVE: To investigate the association of carotid atherosclerosis and serum lipoprotein(a) [Lp(a)] concentrations in subjects with NIDDM. RESEARCH DESIGN AND METHODS: We measured carotid intima-media thickness (IMT) and Lp(a) concentrations in 117 NIDDM subjects. Subjects were divided into tertiles according to IMT values and number of plaques. RESULTS: Serum Lp(a), but not lipid and apoprotein levels, increased significantly with increasing IMT (20.0 +/- 2.3, 24.7 +/- 3.3, and 39.8 +/- 4.3 mg/dl [mean +/- SE], respectively, P < 0.001). Serum Lp(a) increased with increasing number of plaques (18.4 +/- 2.5 mg/dl in 59 subjects with no plaques, 25.8 +/- 2.5 mg/dl in 24 subjects with 1 plaque, and 38.7 +/- 5.1 mg/dl in 34 subjects with more than 1 plaque; P < 0.05). Furthermore, the mean IMT and Lp(a) levels in the subjects with cerebrovascular disease (CD) were significantly higher than in those without CD (1.25 +/- 0.04 mm and 41.2 +/- 4.7 mg/dl vs. 1.08 +/- 0.03 mm and 22.2 +/- 1.9 mg/dl; P < 0.005). The mean IMT and Lp(a) levels were higher in subjects with ischemic heart disease (IHD) than in those without IHD, although statistical significance was not observed (1.21 +/- 0.06 mm and 31.7 +/- 4.7 mg/dl vs. 1.10 +/- 0.03 mm and 27.0 +/- 2.4 mg/dl, respectively). CONCLUSIONS: Elevated serum Lp(a) concentrations are associated with carotid atherosclerosis in NIDDM subjects.