Association between asthma control and Interleukin-17F expression levels in adult patients with atopic asthma

• Published in: Saudi medical journal Vol. 39; no. 7; pp. 662 - 667
• Main Authors: Surachmanto, Eko E, Hatta, Mochammad, Islam, Andi A, Wahid, Syarifuddin
• Format: Journal Article
• Language: English
• Published: Saudi Arabia Prince Sultan Military Medical City (PSMMC) 01.07.2018; Saudi Medical Journal
• Subjects: Adult; Asthma; Asthma - drug therapy; Asthma - genetics; Asthma - metabolism; Asthma - physiopathology; Cross-Sectional Studies; Cytokines; Disease management; Female; Humans; Hypersensitivity, Immediate - drug therapy; Hypersensitivity, Immediate - genetics; Hypersensitivity, Immediate - metabolism; Hypersensitivity, Immediate - physiopathology; Interleukin-17 - genetics; Interleukin-17 - metabolism; Male; Middle Aged; Original; Prognosis; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - metabolism; Young Adult; Indonesia
• ISSN: 0379-5284; 1658-3175
• DOI: 10.15537/smj.2018.7.22055

To investigate the correlation between Interleukin 17 (IL-17F) and the level of asthma control. This is a cross-sectional study of 40 subjects who were diagnosed with atopic asthma. All participants were recruited from the Allergy and Immunology Clinic, Prof. R.D. Kandou General Hospital, Manado, Indonesia, between April 2015 and April 2016. Total serum IL-17F measured by using Enzyme-Linked Immunosorbent Assay methods; and mRNA IL-17F was obtained by using real-time reverse transcriptase polymerase chain reaction. Level of asthma control was quantified by using asthma control test (ACT) scoring system. The correlation between IL-17F, mRNA, and level of asthma control was analyzed by using Pearson's correlation coefficient (r). There is a strong positive correlation between IL-17F serum level and Nathan's ACT-score (r=0.969) which is statistically significant (p less than 0.001). Analysis of the correlation between mRNA IL-17F serum level and Nathan's ACT-score revealed a strong positive correlation (r=0.963), which is statistically significant (p less than 0.001). These findings suggest that IL-17F plays an important role in asthma control. However, the role played by IL-17F in asthma pathogenesis are still questions to be answered.