Immunomodulative effect of glucan and/or glucan supplemented with zinc in albendazole therapy for murine alveolar echinococcosis

• Published in: Parasitology research (1987) Vol. 101; no. 3; pp. 751 - 760
• Main Authors: PORUBCOVA, Jarmila, DVOROZNAKOVA, Emilia, SEVCIKOVA, Zuzana
• Format: Journal Article
• Language: English
• Published: Berlin Berlin/Heidelberg : Springer-Verlag 01.08.2007; Springer
• Subjects: Albendazole - administration & dosage; Animals; Antiparasitic Agents - administration & dosage; Antiparasitic Agents - immunology; B-Lymphocytes - immunology; beta-Glucans - administration & dosage; beta-Glucans - immunology; Biological and medical sciences; Dietary Supplements; Drug Therapy, Combination; Echinococcosis, Pulmonary - drug therapy; Echinococcosis, Pulmonary - immunology; Echinococcus; Fundamental and applied biological sciences. Psychology; General aspects; General aspects and techniques. Study of several systematic groups. Models; Invertebrates; Lymphocyte Activation - immunology; Male; Mice; Pulmonary Alveoli; Specific Pathogen-Free Organisms; T-Lymphocytes - immunology; Treatment Outcome; Zinc - administration & dosage; Zinc - immunology; Infection; Glucan; Albendazole; Parasite; Parasitosis; Helminthiasis; Echinococciasis; Cestode disease; Zinc
• ISSN: 0932-0113; 1432-1955
• DOI: 10.1007/s00436-007-0545-4

The effect of glucan immunomodulator (GI) and glucan supplemented with zinc (GIZn) administered separately or with albendazole (ABZ) on cellular immunity of mice with alveolar echinococcosis was observed. The stimulative effect of GI and GI + ABZ therapy on proliferative response of T lymphocytes was prolonged by GIZn or GIZn + ABZ from week 6 to 14 postinfection (p.i.). The increased proliferation of B lymphocytes was observed during combined therapies GI + ABZ and GIZn + ABZ from week 6 to 12 p.i. Number of splenic CD4 T cells in mice with GI or GI + ABZ therapy was increased only on weeks 6 and 8 p.i. GIZn and GIZn + ABZ therapy prolonged this stimulation from week 6 to 14 p.i. Serum concentration of interferon-γ (IFN-γ) was increased after GIZn therapy and reduced after GI therapy from week 8 to 12 p.i. GIZn + ABZ therapy had the highest effect on the IFN-γ rise from week 8 to 22 p.i. Both GI and GIZn inhibited the serum concentration of interleukin-5 (IL-5) from week 6 p.i. The production of superoxide anion was increased after GI therapy from week 6 to 14 p.i. and after GI + ABZ or GIZn + ABZ therapies from week 12 to 18 p.i. The most effective antiparasitic therapy for alveolar echinococcosis was reached by GIZn + ABZ therapy.