Don't Mess with the DSMB

If the lyrics of the popular Jim Croce song from the early 1970s were adapted for a clinical trialist anthem, the refrain would likely be You don't tug on Superman's cape You don't spit into the wind You don't pull the mask off that old Lone Ranger And you don't mess around...

Full description

Saved in:
Bibliographic Details
Published inThe New England journal of medicine Vol. 363; no. 5; pp. 477 - 478
Main Authors Drazen, Jeffrey M, Wood, Alastair J.J
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 29.07.2010
Subjects
Anticholesteremic Agents - adverse effects
Aortic Valve Stenosis - drug therapy
Azetidines - adverse effects
Cancer
Cardiovascular Diseases - chemically induced
Clinical trials
Clinical Trials Data Monitoring Committees - standards
Diabetes
Diabetes Mellitus, Type 2 - drug therapy
Ezetimibe
Humans
Hypoglycemic Agents - adverse effects
Medical research
Neoplasms - chemically induced
Simvastatin - adverse effects
Thiazolidinediones - adverse effects
United States
United States
Online AccessGet full text

Cover

More Information
Summary:If the lyrics of the popular Jim Croce song from the early 1970s were adapted for a clinical trialist anthem, the refrain would likely be You don't tug on Superman's cape You don't spit into the wind You don't pull the mask off that old Lone Ranger And you don't mess around with the DSMB. Since the DSMB (data and safety monitoring board) is charged with ensuring that clinical equipoise is maintained as trial data are accrued, it is considered very bad, even self-destructive, behavior for people who are involved with the study to interact with DSMB members on trial-related . . .
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Editorial-2
ObjectType-Commentary-1
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMe1007445