Electrophoretically deposited mesoporous magnesium silicate with ordered nanopores as an antibiotic-loaded coating on surface-modified titanium

• Published in: Materials Science & Engineering C Vol. 96; pp. 765 - 775
• Main Authors: Bigham, Ashkan, Saudi, Ahmad, Rafienia, Mohammad, Rahmati, Shahram, Bakhtiyari, Hassan, Salahshouri, Fatemeh, Sattary, Mansoureh, Hassanzadeh-Tabrizi, S.A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2019; Elsevier BV
• Subjects: Alkaline phosphatase; Antibacterial activity; Antibiotics; Bacteria; Bacterial corrosion; Bioactivity; Biocompatibility; Biological activity; Biomedical materials; Body fluids; Cell Line; Coated Materials, Biocompatible - chemistry; Coated Materials, Biocompatible - pharmacokinetics; Coated Materials, Biocompatible - pharmacology; Coatings; Corrosion; Corrosion resistance; Drug delivery; Drug delivery systems; Electrolytic cells; Electrophoresis; Electrophoretic deposition; Humans; Immersion tests (corrosion); Implants, Experimental; In vitro methods and tests; Infections; Magnesium silicates; Magnesium Silicates - chemistry; Magnesium Silicates - pharmacokinetics; Magnesium Silicates - pharmacology; Materials science; Mineralization; Nanopores; Ordered mesoporous magnesium silicate; Osteogenesis; Oxidation; Porosity; Protective coatings; Rifampin; Substrates; Surgery; Surgical implants; Titanium; Titanium - chemistry; Titanium - pharmacokinetics; Titanium - pharmacology; Ordered mesoporous magnesium silicate; Antibacterial activity; Bioactivity; Drug delivery; Corrosion; Electrophoretic deposition
• ISSN: 0928-4931; 1873-0191
• DOI: 10.1016/j.msec.2018.12.013

Infection is quite usual for implants after surgery and a systemic administration of antibiotics causes problems before the eradication of bacteria. Localized drug delivery from implants is an effective way by which the mentioned target can be met. In the current work, ordered mesoporous magnesium silicate (OMMS) is coated on plasma electrolytic oxidation (PEO)-modified titanium (Ti) substrate through electrophoretic deposition (EPD) and rifampin as an antibiotic is loaded on OMMS coating to be applied as an antibacterial coating. The immersion test into simulated body fluid and also potentiodynamic polarization assay are adopted to assess the in vitro bioactivity up to 7 days and corrosion resistance of the specimens, respectively. The double surface coatings of PEO and EPD are achieved on Ti substrate and the thickness for each one is found to be 4 and 25 μm, respectively. Regarding to drug delivery capability of OMMS as the EPD coating, the loading capacity is 25% and release trend sustains up to 96 h. The antibacterial activity and also cell viability of OMMS coating are significantly increased with rifampin loading. The results of our study exhibit that OMMS as a multifunctional coating deposited on the PEO-modified Ti substrate improves corrosion resistance, in vitro bioactivity, alkaline phosphatase activity, and mineralization of the substrate. Moreover, rifampin-loaded OMMS coating is not only able to prevent infection, but it also increases the osteogenesis cells viability. Therefore, rifampin-loaded OMMS coating on Ti is potentially regarded appropriate for orthopedic applications. [Display omitted] •Ordered mesoporous magnesium silicate coating is successfully prepared on the PEO-modified titanium.•In vitro bioactivity potential and corrosion behavior of ordered mesoporous magnesium silicate coating is assessed.•Drug delivery behavior, antibacterial activity, cell viability, alkaline phosphatase activity, and mineralization of Rifampin-loaded OMMS coating are assessed in vitro.