Long noncoding RNA LOXL1-AS1 regulates prostate cancer cell proliferation and cell cycle progression through miR-541-3p and CCND1

Prostate cancer is one of the most frequent malignancies affecting men. Long non-coding RNAs (lncRNAs) are involved in the pathogenesis of prostate cancer. LncRNA LOXL1-AS1 participates in the pathogenesis of the exfoliation syndrome. However, the role of LOXL1-AS1 in cancer remains largely unknown....

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Published inBiochemical and biophysical research communications Vol. 505; no. 2; pp. 561 - 568
Main Authors Long, Bo, Li, Na, Xu, Xi-Xia, Li, Xiao-Xin, Xu, Xin-Jie, Liu, Jie-Ying, Wu, Zhi-Hong
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 28.10.2018
Subjects
60 APPLIED LIFE SCIENCES
CCND1
CELL PROLIFERATION
CYTOPLASM
lncRNA
MEN
miRNA
NEOPLASMS
PATHOGENESIS
PORIFERA
PROSTATE
Prostate cancer
RNA
Cell proliferation
miRNA
lncRNA
CCND1
Prostate cancer
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Summary:Prostate cancer is one of the most frequent malignancies affecting men. Long non-coding RNAs (lncRNAs) are involved in the pathogenesis of prostate cancer. LncRNA LOXL1-AS1 participates in the pathogenesis of the exfoliation syndrome. However, the role of LOXL1-AS1 in cancer remains largely unknown. Here, we found that LOXL1-AS1 down-regulation inhibited prostate cancer cell proliferation and cell cycle progression. RNA sequencing analysis revealed that it regulates the expression of cell cycle-related genes. LOXL1-AS1 is predominantly distributed in the cytoplasm, where it interacts with miR-541-3p. In addition, miR-541-3p targets the cell cycle regulator CCND1 in prostate cancer cells. LOXL1-AS1 down-regulation inhibits the expression of CCND1 and cell cycle progression, whereas these effects are abolished upon miR-541-3p suppression. In summary, our study revealed that LOXL1-AS1 regulates prostate cancer cell proliferation and cell cycle progression through miR-541-3p and CCND1. Modulation of their levels may be used to treat prostate cancer. •LOXL1-AS1 regulates proliferation and cell cycle in prostate cancer cells.•miR-541-3p regulates CCND1 expression in prostate cancer cells.•LOXL1-AS1 sponges and regulates the expression of miR-541-3p.•LOXL1-AS1 regulates proliferation and cell cycle through miR-541-3p and CCND1.
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ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2018.09.160