Integrated preoperative irradiation and radical cystectomy

Thirty patients with stage B 2-C-D 1 and/or grade II–IV transitional cell carcinoma of the bladder were entered into a pilot study of integrated surgery and radiotherapy. Staging laparotomy with formation of an Real loop preceded the delivery of 4000–5000 rad in 4–5 weeks to the pelvis; cystectomy w...

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Published inInternational journal of radiation oncology, biology, physics Vol. 6; no. 5; pp. 607 - 612
Main Authors Sagerman, Robert H., Yu, Woon Sang, Ryoo, Monica C., King, Gerald A., Chung, Chung T., Gunam Emmanuel, I.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.05.1980
Subjects
Adult
Aged
Bladder cancer
Carcinoma, Transitional Cell - radiotherapy
Carcinoma, Transitional Cell - surgery
Carcinoma, Transitional Cell - therapy
Complications of combined therapy
Female
Humans
Male
Middle Aged
Neoplasm Staging
Pilot Projects
Postoperative Complications
Preoperative irradiation
Prognosis
Tumor control
Urinary Bladder - surgery
Urinary Bladder Neoplasms - radiotherapy
Urinary Bladder Neoplasms - surgery
Urinary Bladder Neoplasms - therapy
Tumor control
Complications of combined therapy
Preoperative irradiation
Bladder cancer
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Summary:Thirty patients with stage B 2-C-D 1 and/or grade II–IV transitional cell carcinoma of the bladder were entered into a pilot study of integrated surgery and radiotherapy. Staging laparotomy with formation of an Real loop preceded the delivery of 4000–5000 rad in 4–5 weeks to the pelvis; cystectomy was accomplished in 26 patients 4–8 weeks after completion of irradiation. The program was accomplished without undue difficulty and resulted in a lowering of the clinical stage in 22 of 26 patients; no residual invasive cancer was seen histologically in 8 patients. Although it was formidable, the morbidity rate was not significantly different than it was after cystectomy without preoperative irradiation. The short term survival rate, in conjunction with an analysis of sites of failure, suggests that a prospective study be accomplished to document the validity of this therapeutic approach to bladder cancer; patient selection, surgical technique, and time-dose-volume radiation factors should also be considered.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0360-3016
1879-355X
DOI:10.1016/0360-3016(80)90390-9