No volatile n-nitrosamines detected in blood and urine from patients ingesting daily large amounts of ammonium nitrate

Whole blood and urine from 23 patients ingesting ammonium nitrate daily in amounts varying from 2.5–9 g were analysed for volatile N-nitrosamines. By contrast with reports in the literature N-nitrosodimethylamine and N-nitrosodiethylamine were not found in blood (limit of detection 0.1 μg/kg) but a...

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Bibliographic Details
Published inFood and chemical toxicology Vol. 20; no. 6; pp. 879 - 882
Main Authors ellen, G., schuller, P.L., froeling, P.G.A.M., bruijns, E.
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.01.1982
Subjects
Adolescent
Adult
Female
food contamination
Humans
Male
Middle Aged
Nitrates - administration & dosage
Nitrates - metabolism
Nitrosamines - blood
Nitrosamines - isolation & purification
Nitrosamines - urine
Volatilization
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Summary:Whole blood and urine from 23 patients ingesting ammonium nitrate daily in amounts varying from 2.5–9 g were analysed for volatile N-nitrosamines. By contrast with reports in the literature N-nitrosodimethylamine and N-nitrosodiethylamine were not found in blood (limit of detection 0.1 μg/kg) but a trace of N-nitrosopyrrolidine was found in the blood of one subject. Small amounts of N-nitrosomorpholine in some blood samples and in one blank were believed to be formed during the analysis since morpholine had been added to the samples to indicate artefactual nitrosamine formation. Traces of N-nitrosodimethylamine (0.1 μg/kg) were found in six of the 23 urine samples.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0278-6915
1873-6351
DOI:10.1016/S0015-6264(82)80221-6