Cerebral time domain-NIRS: reproducibility analysis, optical properties, hemoglobin species and tissue oxygen saturation in a cohort of adult subjects

• Published in: Biomedical optics express Vol. 8; no. 11; pp. 4987 - 5000
• Main Authors: Giacalone, Giacomo, Zanoletti, Marta, Contini, Davide, Re, Rebecca, Spinelli, Lorenzo, Roveri, Luisa, Torricelli, Alessandro
• Format: Journal Article
• Language: English
• Published: United States Optical Society of America 01.11.2017
• Subjects: (170.5280) Photon migration; (170.6935) Tissue characterization; (300.6500) Spectroscopy, time-resolved; (170.1470) Blood or tissue constituent monitoring; (170.3660) Light propagation in tissues; (120.3890) Medical optics instrumentation
• ISSN: 2156-7085; 2156-7085
• DOI: 10.1364/BOE.8.004987

The reproducibility of cerebral time-domain near-infrared spectroscopy (TD-NIRS) has not been investigated so far. Besides, reference intervals of cerebral optical properties, of absolute concentrations of deoxygenated-hemoglobin (HbR), oxygenated-hemoglobin (HbO), total hemoglobin (HbT) and tissue oxygen saturation (StO ) and their variability have not been reported. We have addressed these issues on a sample of 88 adult healthy subjects. TD-NIRS measurements at 690, 785, 830 nm were fitted with the diffusion model for semi-infinite homogenous media. Reproducibility, performed on 3 measurements at 5 minutes intervals, ranges from 1.8 to 6.9% for each of the hemoglobin species. The mean ± SD global values of HbR, HbO, HbT, StO are respectively 24 ± 7 μM, 33.3 ± 9.5 μM, 57.4 ± 15.8 μM, 58 ± 4.2%. StO displays the narrowest range of variability across brain regions.