Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study

• Published in: Diabetes care Vol. 21; no. 6; pp. 949 - 958
• Main Authors: VALLE, T, TUOMILEHTO, J, TUOMILEHTO-WOLF, E, EHNHOLM, C, BLASCHAK, J, LANGEFELD, C. D, WATANABE, R. M, MAGNUSON, V, ALLY, D. S, HAGOPIAN, W. A, ROSS, E, BUCHANAN, T. A, BERGMAN, R. N, COLLINS, F, BOEHNKE, M, GHOSH, S, HAUSER, E. R, ERIKSSON, J, NYLUND, S. J, KOHTAMAKI, K, TOIVANEN, L, VIDGREN, G
• Format: Journal Article
• Language: English
• Published: Alexandria, VA American Diabetes Association 01.06.1998
• Subjects: Age; Age of Onset; Aged; Biological and medical sciences; Blood Glucose - analysis; Diabetes; Diabetes Mellitus, Type 2 - blood; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - physiopathology; Diabetes. Impaired glucose tolerance; Disease; Endocrine pancreas. Apud cells (diseases); Endocrinopathies; Etiopathogenesis. Screening. Investigations. Target tissue resistance; Families & family life; Fasting; Female; Finland; Genetic Predisposition to Disease; Genetics; Genomes; Genotype; Glucose; Humans; Insulin - blood; Insulin resistance; International Cooperation; Male; Medical sciences; Middle Aged; Nuclear Family; Parents & parenting; Peptides; Phenotype; Quantitative Trait, Heritable; Research design; Sex Characteristics; Siblings; United States; United States; North America; Europe; America; Finland; United States > US; Endocrinopathy; Genetic mapping; Human; Family study; Scientific research; Genome; Non insulin dependent diabetes; Epidemiology
• ISSN: 0149-5992; 1935-5548
• DOI: 10.2337/diacare.21.6.949

Mapping genes for NIDDM. Design of the Finland-United States Investigation of NIDDM Genetics (FUSION) Study. T Valle , J Tuomilehto , R N Bergman , S Ghosh , E R Hauser , J Eriksson , S J Nylund , K Kohtamäki , L Toivanen , G Vidgren , E Tuomilehto-Wolf , C Ehnholm , J Blaschak , C D Langefeld , R M Watanabe , V Magnuson , D S Ally , W A Hagopian , E Ross , T A Buchanan , F Collins and M Boehnke Department of Epidemiology and Health Promotion, National Public Health Institute, Helsinki, Finland. timo.valle@ktl.fi Abstract OBJECTIVE: To map and identify susceptibility genes for NIDDM and for the intermediate quantitative traits associated with NIDDM. RESEARCH DESIGN AND METHODS: We describe the methodology and sample of the Finland-United States Investigation of NIDDM Genetics (FUSION) study. The whole genome search approach is being applied in studies of several different ethnic groups to locate susceptibility genes for NIDDM. Detailed description of the study materials and designs of such studies are important, particularly when comparing the findings in these studies and when combining different data sets. RESULTS: Using a careful selection strategy, we have ascertained 495 families with confirmed NIDDM in at least two siblings and no history of IDDM among the first-degree relatives. These families were chosen from more than 22,000 NIDDM patients, representative of patients with NIDDM in the Finnish population. In a subset of families, a spouse and offspring were sampled, and they participated in a frequently sampled intravenous glucose tolerance test (FSIGT) analyzed with the Minimal Model. An FSIGT was completed successfully for at least two nondiabetic offspring in 156 families with a confirmed nondiabetic spouse and no history of IDDM in first-degree relatives. CONCLUSIONS: Our work demonstrates the feasibility of collecting a large number of affected sib-pair families with NIDDM to provide data that will enable a whole genome search approach, including linkage analysis.