Analysis of skin lesions using laminar optical tomography

Evaluation of suspicious skin lesions by dermatologists is usually accomplished using white light examination and direct punch or surgical biopsy. However, these techniques can be imprecise for estimating a lesion's margin or level of dermal invasion when planning surgical resection. Laminar op...

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Bibliographic Details
Published inBiomedical optics express Vol. 3; no. 7; pp. 1701 - 1712
Main Authors Muldoon, Timothy J, Burgess, Sean A, Chen, Brenda R, Ratner, Désirée, Hillman, Elizabeth M C
Format Journal Article
LanguageEnglish
Published United States Optical Society of America 01.07.2012
Subjects
Optics in Cancer Research
(170.3890) Medical optics instrumentation
(170.3880) Medical and biological imaging
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Summary:Evaluation of suspicious skin lesions by dermatologists is usually accomplished using white light examination and direct punch or surgical biopsy. However, these techniques can be imprecise for estimating a lesion's margin or level of dermal invasion when planning surgical resection. Laminar optical tomography (LOT) is an imaging technique capable of acquiring depth-sensitive information within scattering tissues. Here, we explore whether LOT data can be used to predict the depth and thickness of pigmented lesions using a range of simulations and phantom models. We then compare these results to LOT data acquired on normal and malignant skin lesions in vivo.
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ISSN:2156-7085
2156-7085
DOI:10.1364/BOE.3.001701