Subinhibitory Dalbavancin Attenuates Exotoxin Production from Methicillin-Sensitive and Methicillin-Resistant Staphylococcus aureus In Vitro

This study investigated the effects of subinhibitory doses of the lipoglycopeptide antibiotic dalbavancin on toxin production toxin production levels were compared to those seen with the natural glycopeptide antibiotic vancomycin and with representative beta-lactam and oxazolidinone antibiotics. Whi...

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Published inAntimicrobial agents and chemotherapy Vol. 61; no. 11
Main Authors Hobdey, Sarah E, Katahira, Eva J, Dockstader, Pamela, Davidson, Stephen M, Bond, Laura, Bolz, Devin D, Bryant, Amy E, Stevens, Dennis L
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.11.2017
Subjects
Clinical Therapeutics
subinhibitory antibiotics
Staphylococcus aureus
toxin production
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Summary:This study investigated the effects of subinhibitory doses of the lipoglycopeptide antibiotic dalbavancin on toxin production toxin production levels were compared to those seen with the natural glycopeptide antibiotic vancomycin and with representative beta-lactam and oxazolidinone antibiotics. While neither dalbavancin nor vancomycin adversely affected toxin production, of these glycopeptide antibiotics, only dalbavancin significantly attenuated toxin production at subinhibitory concentrations. These findings support the recent success of dalbavancin for treatment of staphylococcal infections.
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Present address: Pamela Dockstader, Idaho State University, Meridian, Idaho, USA; Stephen M. Davidson, University of Arizona, Tucson, Arizona, USA.
Citation Hobdey SE, Katahira EJ, Dockstader P, Davidson SM, Bond L, Bolz DD, Bryant AE, Stevens DL. 2017. Subinhibitory dalbavancin attenuates exotoxin production from methicillin-sensitive and methicillin-resistant Staphylococcus aureus in vitro. Antimicrob Agents Chemother 61:e01090-17. https://doi.org/10.1128/AAC.01090-17.
ISSN:0066-4804
1098-6596
DOI:10.1128/AAC.01090-17