Antimicrobial Susceptibility Testing for Helicobacter pylori Is Now Widely Available: When, How, Why

Theoretically, proton pump inhibitor or vonoprazan plus amoxicillin dual therapy are candidates for an empiric first-line choice, especially in Asia, but the regimen has not yet been optimized for use in Western countries. AML offers a reflex option for stool antigen or polymerase chain reaction tes...

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Bibliographic Details
Published inThe American journal of gastroenterology Vol. 117; no. 4; pp. 524 - 528
Main Authors Graham, David Y, Moss, Steven F
Format Journal Article
LanguageEnglish
Published United States Wolters Kluwer Health Medical Research, Lippincott Williams & Wilkins 01.04.2022
Subjects
Anti-Bacterial Agents - pharmacology
Anti-Bacterial Agents - therapeutic use
Anti-Infective Agents
Antibiotics
Antimicrobial agents
Biopsy
Clarithromycin
Drug resistance
Drug Resistance, Bacterial
Endoscopy
Glycerol
Helicobacter Infections - diagnosis
Helicobacter Infections - drug therapy
Helicobacter pylori
Histology
Humans
Laboratories
Microbial Sensitivity Tests
Patients
R&D
Research & development
Success
United States > US
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Summary:Theoretically, proton pump inhibitor or vonoprazan plus amoxicillin dual therapy are candidates for an empiric first-line choice, especially in Asia, but the regimen has not yet been optimized for use in Western countries. AML offers a reflex option for stool antigen or polymerase chain reaction testing using NGS to reflexively test stool for the 6 commonly prescribed antibiotics. [...]the US Food and Drug Administration warning about serious long-term side effects of quinolone therapy dictate that fluoroquinolones be used only in susceptibility-based therapies. D.Y.G. is supported in part by the Office of Research and Development Medical Research Services Department of Veterans Affairs, Public Health Service grant DK56338, which funds the Texas Medical Center Digestive Diseases Center.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:0002-9270
1572-0241
DOI:10.14309/ajg.0000000000001659