Mus musculus Papillomavirus 1: a New Frontier in Animal Models of Papillomavirus Pathogenesis

Animal models of viral pathogenesis are essential tools in human disease research. Human papillomaviruses (HPVs) are a significant public health issue due to their widespread sexual transmission and oncogenic potential. Infection-based models of papillomavirus pathogenesis have been complicated by t...

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Bibliographic Details
Published inJournal of virology Vol. 94; no. 9
Main Authors Spurgeon, Megan E, Lambert, Paul F
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 16.04.2020
Subjects
Animals
Carcinogenesis
Disease Models, Animal
Gem
Mice
Papillomaviridae - metabolism
Papillomaviridae - pathogenicity
Papillomavirus Infections - veterinary
Papillomavirus Infections - virology
viral pathogenesis
animal models
viral oncology
human papillomavirus
papillomavirus
MmuPV1
murine papillomavirus
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Summary:Animal models of viral pathogenesis are essential tools in human disease research. Human papillomaviruses (HPVs) are a significant public health issue due to their widespread sexual transmission and oncogenic potential. Infection-based models of papillomavirus pathogenesis have been complicated by their strict species and tissue specificity. In this Gem, we discuss the discovery of a murine papillomavirus, Mus musculus papillomavirus 1 (MmuPV1), and how its experimental use represents a major advancement in models of papillomavirus-induced pathogenesis/carcinogenesis, and their transmission.
Bibliography:Citation Spurgeon ME, Lambert PF. 2020. Mus musculus papillomavirus 1: a new frontier in animal models of papillomavirus pathogenesis. J Virol 94:e00002-20. https://doi.org/10.1128/JVI.00002-20.
ISSN:0022-538X
1098-5514
DOI:10.1128/JVI.00002-20