The effect of aminoglycoside-induced adaptive resistance on the antibacterial activity of other antibiotics against Pseudomonas aeruginosa in vitro

• Published in: Journal of antimicrobial chemotherapy Vol. 38; no. 5; pp. 853 - 858
• Main Authors: BARCLAY, M. L, BEGG, E. J, CHAMBERS, S. T, PEDDIE, B. A
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.11.1996
• Subjects: Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Aztreonam - pharmacology; Biological and medical sciences; Ceftazidime - pharmacology; Ciprofloxacin - pharmacology; Colony Count, Microbial; Drug Resistance, Microbial; Gentamicins - pharmacology; Imipenem - pharmacology; Medical sciences; Pharmacology. Drug treatments; Piperacillin - pharmacology; Pseudomonas aeruginosa; Pseudomonas aeruginosa - drug effects; Pseudomonas aeruginosa - growth & development; Rifampin - pharmacology; Pseudomonadales; Gentamicin; Penicillin derivatives; Carbapenem derivatives; Fluoroquinolone derivatives; Rifampicin; Piperacillin; Bacteria; Pseudomonadaceae; Pseudomonas aeruginosa; Ceftazidime; Quinolone derivatives; In vitro; Monobactam derivatives; Biological activity; Bactericidal effect; Resistance; Antibiotic; Cephalosporin derivatives; Aminoglycoside; Azetidine derivatives; Aztreonam; Antibacterial agent; Ciprofloxacin; Imipenem
• ISSN: 0305-7453; 1460-2091
• DOI: 10.1093/jac/38.5.853

The effect of gentamicin-induced adaptive resistance on the antibacterial activity of six non-aminoglycoside antibiotics was studied. Adaptive resistance was induced in Pseudomonas aeruginosa in a dynamic in-vitro model of infection. The bactericidal effect of ceftazidime, imipenem, aztreonam, ciprofloxacin, and piperacillin was not altered in the presence of adaptive resistance but the effect of rifampicin was increased.