The levels of leptin, adiponectin, and resistin in normal weight, overweight, and obese pregnant women with and without preeclampsia

• Published in: American journal of obstetrics and gynecology Vol. 193; no. 3; pp. 979 - 983
• Main Authors: Hendler, Israel, Blackwell, Sean C., Mehta, Shobha H., Whitty, Janice E., Russell, Evelyne, Sorokin, Yoram, Cotton, David B.
• Format: Journal Article Conference Proceeding
• Language: English
• Published: Philadelphia, PA Mosby, Inc 01.09.2005; Elsevier
• Subjects: Adiponectin; Biological and medical sciences; Body Mass Index; Cross-Sectional Studies; Diseases of mother, fetus and pregnancy; Female; Gynecology. Andrology. Obstetrics; Hormones, Ectopic - blood; Humans; Intercellular Signaling Peptides and Proteins - blood; Leptin; Leptin - blood; Medical sciences; Metabolic diseases; Obesity; Obesity - blood; Pre-Eclampsia - blood; Pre-Eclampsia - physiopathology; Preeclampsia; Pregnancy; Pregnancy. Fetus. Placenta; Resistin; Pregnancy; Obesity; Preeclampsia; Leptin; Resistin; Adiponectin; Human; Adipocytokine; Preeclampsia Obesity Leptin Resistin Adiponectin Pregnancy; Pregnancy disorders; Gynecology; Body weight; Nutrition disorder; Obstetrics; Pregnancy toxemia; Overweight; Adult; Female; Nutritional status
• ISSN: 0002-9378; 1097-6868
• DOI: 10.1016/j.ajog.2005.06.041

The purpose of this study was to compare adipokines' levels between women with and without preeclampsia based on maternal body mass index (BMI). This was a cross-sectional study among third-trimester pregnancies with preeclampsia (PIH) compared with normotensive controls. Serum levels of adiponectin, leptin, and resistin were measured before delivery by radioimmunoassay or enzyme-linked immunosorbent assay (ELISA). The study included 22 normotensive and 77 PIH women. Leptin levels increased with maternal BMI. In patients with severe preeclampsia, overweight, and obese women had increased leptin levels (33.4 ± 14.8 vs 23.0 ± 10.8 ng/mL respectively, P = .02), and decreased adiponectin levels (8.4 ± 5.3 vs 12.6 ± 6.0 ng/mL, P = .03) compared with normal weight women. In women with BMI <25 kg/m 2, adiponectin levels increased in patients with preeclampsia compared with controls (11.5 ± 5.6 vs 9.6 ± 4.6 and 7.0 ± 3.2 ng/mL, respectively, P = .005). There was no association between resistin levels and preeclampsia or maternal BMI. Women with severe preeclampsia and BMI ≥25 kg/m 2 have decreased adiponectin and increased leptin levels, while normal weight women with preeclampsia have increased adiponectin levels.