Alveolar cleft osteoplasty using tissue-engineered osteogenic material

• Published in: International journal of oral and maxillofacial surgery Vol. 35; no. 6; pp. 551 - 555
• Main Authors: Hibi, H., Yamada, Y., Ueda, M., Endo, Y.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 01.06.2006; Elsevier
• Subjects: Alveolar Process - abnormalities; Alveoloplasty - methods; Biological and medical sciences; Bone Regeneration - physiology; Bone Transplantation - methods; Child; Dentistry; Female; Humans; Maxilla - abnormalities; Maxilla - surgery; Medical sciences; Mesenchymal Stem Cell Transplantation - methods; Osteogenesis - physiology; Otorhinolaryngology. Stomatology; Platelet Transfusion; Tissue Engineering - methods; Tomography, X-Ray Computed; Osteoplasty; Tissue; Treatment; Malformation; Stomatology; Surgery; Congenital cleft; Congenital disease; Tooth alveolus
• ISSN: 0901-5027; 1399-0020
• DOI: 10.1016/j.ijom.2005.12.007

The use of tissue-engineered osteogenic material comprising platelet-rich plasma and autologous mesenchymal stem cells isolated, expanded and induced to osteogenic potential in bone augmentation procedures as a replacement for autologous bone grafts, offers predictable results with minimal donor-site morbidity. This material was applied for an alveolar cleft osteoplasty of a 9-year-old female patient. Serial computed tomograms showed the regenerated bone extending from the cleft walls after 3 months and bridging the cleft after 6 months, with 79.1% of the grafted region after 9 months at the time when the canine and lateral incisor in the affected side erupted in the reconstructed alveolar ridge.