IL-1RN VNTR, IL-2(-330), and IL-4 VNTR gene polymorphisms in patients with chronic rhinosinusitis with sinonasal polyposis

• Published in: Turkish journal of medical sciences Vol. 49; no. 5; pp. 1411 - 1417
• Main Authors: Kuran, Gökhan, Aslan, Hüseyin, Haytoğlu, Süheyl, Özalp Yüreğir, Özge, Tuğ Bozdoğan, Sevcan
• Format: Journal Article
• Language: English
• Published: Turkey The Scientific and Technological Research Council of Turkey 24.10.2019
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Alleles; Case-Control Studies; Chronic Disease; Female; Genetic Predisposition to Disease - genetics; Humans; Interleukin 1 Receptor Antagonist Protein - genetics; Interleukin-2 - genetics; Interleukin-4 - genetics; Male; Middle Aged; Minisatellite Repeats - genetics; Nasal Polyps - genetics; Paranasal Sinus Diseases - genetics; Polymorphism, Single Nucleotide - genetics; Rhinitis - genetics; Sinusitis - genetics; Young Adult; IL-4 VNTR; Nasal polyposis; gene polymorphism; IL-1RN VNTR; IL-2(-330)
• ISSN: 1300-0144; 1303-6165
• DOI: 10.3906/sag-1710-186

Sinonasal polyposis is a complex chronic disease displaying contributions from multiple genetic and environmental factors. In this study, we analyzed possible genetic factors that increase susceptibility to this widespread inflammatory disease. A total of 176 adult patients, including 78 patients with sinonasal polyposis and 98 healthy controls, were analyzed for IL-1RN VNTR, IL-2(-330), and IL-4 VNTR gene polymorphisms using polymerase chain reaction and enzyme restriction. IL-1RN and IL-4 VNTR polymorphisms were notably associated with sinonasal polyposis (P = 0.0001 and P = 0.036, respectively); however, regarding the IL-2(-330) gene polymorphism, no significant difference was shown between the patient and control groups (P = 0.235). Our study indicates that the RN2 allele of IL-1RN and the RP1 allele of IL-4 might be risk factors for developing sinonasal polyposis.