Evaluation of the in vitro schistosomicidal, leishmanicidal, and trypanocidal activities of the capsaicin metabolite, Capsicum frutescens , and Capsicum baccatum extracts and of their analysis of the main constituents by HPLC/UV and CG/MS

• Published in: Natural product research Vol. 38; no. 4; pp. 679 - 684
• Main Authors: Vaz Soares Martins, Sandra, Cristina Coelho Britto, Angélica, Tozzati, Marcos Gomide, Magalhães, Lizandra Guidi, Silva, Márcio Luis Andrade E, Januário, Ana Helena, Pauletti, Patrícia Mendonça, Crotti, Antônio Eduardo Miller, Passos, Amanda Vargas Dos, Jesus, Ester Gonçalves de, Peixoto, Amanda Diniz, Medeiros, Gabriela Dos Santos, Santos, Mário F C, Cunha, Wilson Roberto
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis Ltd 01.02.2024
• Subjects: Capsaicin; Capsicum baccatum; Capsicum frutescens; Chemical analysis; Constituents; Developing countries; High-performance liquid chromatography; LDCs; Liquid chromatography; Lysis; Metabolites; capsaicinoids; Capsicum genus; neglected tropical diseases
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2023.2187793

Neglected tropical diseases are significant causes of death and temporary or permanent disability for millions living in developing countries. Unfortunately, there is no effective treatment for these diseases. Thus, this work aimed to conduct a chemical analysis using HPLC/UV and GC/MS to identify the major constituents of the hydroalcoholic extracts of and fruits, evaluating these extracts and their constituents' schistosomicidal, leishmanicidal and trypanocidal activities. The results obtained for the extracts of are better when compared to those obtained for , which can be related to the different concentrations of capsaicin ( ) present in the extracts. The lysis of trypomastigote forms results for capsaicin ( ) led to a significant value of IC = 6.23 µM. Thus, the results point to capsaicin ( ) as a possible active constituent in these extracts.