Mortality and Cardiovascular Disease in Type 1 and Type 2 Diabetes

• Published in: The New England journal of medicine Vol. 376; no. 15; pp. 1407 - 1418
• Main Authors: Rawshani, Aidin, Rawshani, Araz, Franzén, Stefan, Eliasson, Björn, Svensson, Ann-Marie, Miftaraj, Mervete, McGuire, Darren K, Sattar, Naveed, Rosengren, Annika, Gudbjörnsdottir, Soffia
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 13.04.2017
• Subjects: Adolescent; Adult; Age; Age of Onset; Aged; Cardiac and Cardiovascular Systems; Cardiovascular disease; Cardiovascular Diseases; Cardiovascular Diseases - epidemiology; Cardiovascular Diseases - etiology; Cardiovascular Diseases - mortality; complications; Coronary artery disease; Death; Diabetes; Diabetes Mellitus; Diabetes mellitus (insulin dependent); Diabetes mellitus (non-insulin dependent); Diabetes Mellitus, Type 1 - complications; Diabetes Mellitus, Type 1 - mortality; Diabetes Mellitus, Type 2 - complications; Diabetes Mellitus, Type 2 - mortality; Endocrinology and Diabetes; Endokrinologi och diabetes; epidemiology; etiology; Female; Heart attacks; Heart diseases; Heart failure; Hospitalization; Hospitalization - trends; Humans; Incidence; Insulin resistance; Kardiologi; Male; Metabolism; Middle Aged; Mortality; Mortality - trends; Patients; Proportional Hazards Models; Registries; Risk Factors; Sweden; Sweden - epidemiology; Trends; Type 1; Type 2; Sweden
• ISSN: 0028-4793; 1533-4406; 1533-4406
• DOI: 10.1056/NEJMoa1608664

Patients with type 1 or type 2 diabetes in Sweden were studied to examine trends in mortality and cardiovascular disease incidence between 1998 and 2014. Both outcomes declined substantially, although fatal outcomes declined less among patients with type 2 diabetes than among controls. Diabetes mellitus is a complex and heterogeneous group of chronic metabolic diseases that are characterized by hyperglycemia. Type 1 diabetes occurs predominantly in young people (diagnosis at 30 years of age or younger) and is generally thought to be precipitated by an immune-associated destruction of insulin-producing pancreatic beta cells, leading to insulin deficiency and an absolute need for exogenous insulin replacement. 1 Type 2 diabetes is a progressive metabolic disease that is characterized by insulin resistance and eventual functional failure of pancreatic beta cells. 2 The prevalence of type 2 diabetes has been increasing dramatically over the past few decades, 3 with projections . . .