Fast and slow Ca2+ -dependent hyperpolarization mechanisms connect membrane potential and sleep homeostasis
Highlights • Cortical neurons may have an intrinsic ability to initiate a slow firing rhythm. • The cortical firing pattern may actively regulate sleep and wake states. • Ca2+ -dependent hyperpolarization may control rhythmic firing. • Ion channels and kinases involved in Ca2+ signaling regulate sle...
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Published in | Current opinion in neurobiology Vol. 44; pp. 212 - 221 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Elsevier Ltd
01.06.2017
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Subjects | |
Online Access | Get full text |
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Summary: | Highlights • Cortical neurons may have an intrinsic ability to initiate a slow firing rhythm. • The cortical firing pattern may actively regulate sleep and wake states. • Ca2+ -dependent hyperpolarization may control rhythmic firing. • Ion channels and kinases involved in Ca2+ signaling regulate sleep duration. • Sleep-regulating kinases may act on ion channels to achieve sleep homeostasis. |
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Bibliography: | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 |
ISSN: | 0959-4388 1873-6882 |
DOI: | 10.1016/j.conb.2017.05.007 |