Fast and slow Ca2+ -dependent hyperpolarization mechanisms connect membrane potential and sleep homeostasis

Highlights • Cortical neurons may have an intrinsic ability to initiate a slow firing rhythm. • The cortical firing pattern may actively regulate sleep and wake states. • Ca2+ -dependent hyperpolarization may control rhythmic firing. • Ion channels and kinases involved in Ca2+ signaling regulate sle...

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Published inCurrent opinion in neurobiology Vol. 44; pp. 212 - 221
Main Authors Ode, Koji L, Katsumata, Takahiro, Tone, Daisuke, Ueda, Hiroki R
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.06.2017
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Summary:Highlights • Cortical neurons may have an intrinsic ability to initiate a slow firing rhythm. • The cortical firing pattern may actively regulate sleep and wake states. • Ca2+ -dependent hyperpolarization may control rhythmic firing. • Ion channels and kinases involved in Ca2+ signaling regulate sleep duration. • Sleep-regulating kinases may act on ion channels to achieve sleep homeostasis.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0959-4388
1873-6882
DOI:10.1016/j.conb.2017.05.007