Plasma Concentration of Cortisol Negatively Associates with Platelet Reactivity in Older Subjects
The interaction of platelets with steroid hormones is poorly investigated. Age is one of the factors that increase the risk of pathological platelet reactivity and thrombosis. The aim of this study was to assess whether there were associations between platelet reactivity and plasma cortisol levels i...
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| Published in | International journal of molecular sciences Vol. 24; no. 1; p. 717 |
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| Main Authors | , , , , , , , |
| Format | Journal Article |
| Language | English |
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31.12.2022
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| ISSN | 1422-0067 1422-0067 |
| DOI | 10.3390/ijms24010717 |
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| Abstract | The interaction of platelets with steroid hormones is poorly investigated. Age is one of the factors that increase the risk of pathological platelet reactivity and thrombosis. The aim of this study was to assess whether there were associations between platelet reactivity and plasma cortisol levels in volunteers aged 60–65 years. For this purpose, impedance aggregometry in whole blood measured after arachidonic acid, collagen, or ADP stimulation was used to estimate platelet reactivity and mass spectrometry was used to measure peripheral plasma cortisol concentration. Statistically significant negative correlations were observed between cortisol concentration and platelet reactivity in response to arachidonic acid and ADP, but not to collagen. The presented results suggest for the very first time that cortisol is a new endogenous modulator of platelet reactivity in the elderly population. |
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| AbstractList | The interaction of platelets with steroid hormones is poorly investigated. Age is one of the factors that increase the risk of pathological platelet reactivity and thrombosis. The aim of this study was to assess whether there were associations between platelet reactivity and plasma cortisol levels in volunteers aged 60-65 years. For this purpose, impedance aggregometry in whole blood measured after arachidonic acid, collagen, or ADP stimulation was used to estimate platelet reactivity and mass spectrometry was used to measure peripheral plasma cortisol concentration. Statistically significant negative correlations were observed between cortisol concentration and platelet reactivity in response to arachidonic acid and ADP, but not to collagen. The presented results suggest for the very first time that cortisol is a new endogenous modulator of platelet reactivity in the elderly population.The interaction of platelets with steroid hormones is poorly investigated. Age is one of the factors that increase the risk of pathological platelet reactivity and thrombosis. The aim of this study was to assess whether there were associations between platelet reactivity and plasma cortisol levels in volunteers aged 60-65 years. For this purpose, impedance aggregometry in whole blood measured after arachidonic acid, collagen, or ADP stimulation was used to estimate platelet reactivity and mass spectrometry was used to measure peripheral plasma cortisol concentration. Statistically significant negative correlations were observed between cortisol concentration and platelet reactivity in response to arachidonic acid and ADP, but not to collagen. The presented results suggest for the very first time that cortisol is a new endogenous modulator of platelet reactivity in the elderly population. The interaction of platelets with steroid hormones is poorly investigated. Age is one of the factors that increase the risk of pathological platelet reactivity and thrombosis. The aim of this study was to assess whether there were associations between platelet reactivity and plasma cortisol levels in volunteers aged 60–65 years. For this purpose, impedance aggregometry in whole blood measured after arachidonic acid, collagen, or ADP stimulation was used to estimate platelet reactivity and mass spectrometry was used to measure peripheral plasma cortisol concentration. Statistically significant negative correlations were observed between cortisol concentration and platelet reactivity in response to arachidonic acid and ADP, but not to collagen. The presented results suggest for the very first time that cortisol is a new endogenous modulator of platelet reactivity in the elderly population. |
| Author | Karolczak, Kamil Kostanek, Joanna Soltysik, Bartlomiej Witas, Piotr Jakub Kostka, Tomasz Konieczna, Lucyna Watala, Cezary Baczek, Tomasz |
| AuthorAffiliation | 1 Department of Haemostatic Disorders, Medical University of Lodz, ul. Mazowiecka 6/8, 92-215 Lodz, Poland 3 Department of Geriatrics, Healthy Aging Research Center (HARC), Medical University of Lodz, pl. Hallera 1, 90-647 Lodz, Poland 2 Department of Pharmaceutical Chemistry, Medical University of Gdańsk, ul. Hallera 107, 80-416 Gdańsk, Poland |
| AuthorAffiliation_xml | – name: 3 Department of Geriatrics, Healthy Aging Research Center (HARC), Medical University of Lodz, pl. Hallera 1, 90-647 Lodz, Poland – name: 2 Department of Pharmaceutical Chemistry, Medical University of Gdańsk, ul. Hallera 107, 80-416 Gdańsk, Poland – name: 1 Department of Haemostatic Disorders, Medical University of Lodz, ul. Mazowiecka 6/8, 92-215 Lodz, Poland |
| Author_xml | – sequence: 1 givenname: Kamil surname: Karolczak fullname: Karolczak, Kamil – sequence: 2 givenname: Lucyna orcidid: 0000-0003-1015-0478 surname: Konieczna fullname: Konieczna, Lucyna – sequence: 3 givenname: Bartlomiej orcidid: 0000-0002-1382-3757 surname: Soltysik fullname: Soltysik, Bartlomiej – sequence: 4 givenname: Tomasz orcidid: 0000-0003-0437-650X surname: Kostka fullname: Kostka, Tomasz – sequence: 5 givenname: Piotr Jakub surname: Witas fullname: Witas, Piotr Jakub – sequence: 6 givenname: Joanna orcidid: 0000-0001-7979-9641 surname: Kostanek fullname: Kostanek, Joanna – sequence: 7 givenname: Tomasz surname: Baczek fullname: Baczek, Tomasz – sequence: 8 givenname: Cezary orcidid: 0000-0002-5627-7872 surname: Watala fullname: Watala, Cezary |
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| Snippet | The interaction of platelets with steroid hormones is poorly investigated. Age is one of the factors that increase the risk of pathological platelet reactivity... |
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| SubjectTerms | Adenosine Diphosphate - pharmacology Aged Arachidonic Acid - pharmacology Blood Platelets Collagen - pharmacology Humans Hydrocortisone - pharmacology Platelet Aggregation Platelet Aggregation Inhibitors - pharmacology |
| Title | Plasma Concentration of Cortisol Negatively Associates with Platelet Reactivity in Older Subjects |
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