Plasma Concentration of Cortisol Negatively Associates with Platelet Reactivity in Older Subjects

The interaction of platelets with steroid hormones is poorly investigated. Age is one of the factors that increase the risk of pathological platelet reactivity and thrombosis. The aim of this study was to assess whether there were associations between platelet reactivity and plasma cortisol levels i...

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Published inInternational journal of molecular sciences Vol. 24; no. 1; p. 717
Main Authors Karolczak, Kamil, Konieczna, Lucyna, Soltysik, Bartlomiej, Kostka, Tomasz, Witas, Piotr Jakub, Kostanek, Joanna, Baczek, Tomasz, Watala, Cezary
Format Journal Article
LanguageEnglish
Published Switzerland MDPI 31.12.2022
Subjects
Adenosine Diphosphate - pharmacology
Aged
Arachidonic Acid - pharmacology
Blood Platelets
Collagen - pharmacology
Humans
Hydrocortisone - pharmacology
Platelet Aggregation
Platelet Aggregation Inhibitors - pharmacology
atherosclerosis
cortisol
platelet reactivity
aging
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Summary:The interaction of platelets with steroid hormones is poorly investigated. Age is one of the factors that increase the risk of pathological platelet reactivity and thrombosis. The aim of this study was to assess whether there were associations between platelet reactivity and plasma cortisol levels in volunteers aged 60–65 years. For this purpose, impedance aggregometry in whole blood measured after arachidonic acid, collagen, or ADP stimulation was used to estimate platelet reactivity and mass spectrometry was used to measure peripheral plasma cortisol concentration. Statistically significant negative correlations were observed between cortisol concentration and platelet reactivity in response to arachidonic acid and ADP, but not to collagen. The presented results suggest for the very first time that cortisol is a new endogenous modulator of platelet reactivity in the elderly population.
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ISSN:1422-0067
1422-0067
DOI:10.3390/ijms24010717