In-vitro development of resistance to beta-lactam antibiotics in Streptococcus pneumoniae

Selection of resistant mutants was induced in broth by exposing pneumococci to serial sub-inhibitory concentrations of various beta-lactam antibiotics. Aminopenicillins selected for resistance to themselves and to cephalosporins although cephalosporins tended to select for resistance to their own cl...

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Bibliographic Details
Published inJournal of antimicrobial chemotherapy Vol. 36; no. 2; p. 417
Main Authors Carsenti-Etesse, H, Durant, J, De Salvador, F, Bensoussan, M, Bensoussan, F, Pradier, C, Thabaut, A, Dellamonica, P
Format Journal Article
LanguageEnglish
Published England 01.08.1995
Subjects
Anti-Bacterial Agents - pharmacology
beta-Lactam Resistance - genetics
Cephalosporins - pharmacology
Chromosomes, Bacterial - chemistry
DNA, Bacterial - chemistry
DNA, Bacterial - isolation & purification
Microbial Sensitivity Tests
Mutation
Penicillins - pharmacology
Streptococcus pneumoniae - drug effects
Streptococcus pneumoniae - genetics
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Summary:Selection of resistant mutants was induced in broth by exposing pneumococci to serial sub-inhibitory concentrations of various beta-lactam antibiotics. Aminopenicillins selected for resistance to themselves and to cephalosporins although cephalosporins tended to select for resistance to their own class, with the exception of cefixime which seems to select cross-resistant organisms.
ISSN:0305-7453
DOI:10.1093/jac/36.2.417