Comparison the analgesic effect of magnesium sulphate and Ketorolac in the treatment of renal colic patients: Double-blind clinical trial study

• Published in: The American journal of emergency medicine Vol. 37; no. 6; pp. 1033 - 1036
• Main Authors: Maleki Verki, Mohammadreza, Porozan, Samaneh, Motamed, Hassan, Fahimi, Mohammad Ali, Aryan, Adel
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2019; Elsevier Limited
• Subjects: Acetylcholine; Adult; Age; Analgesics; Analgesics - standards; Analgesics - therapeutic use; Analysis of Variance; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - standards; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Blood pressure; Clinical trials; Contraction; Demographics; Double-Blind Method; Double-blind studies; Emergency medical care; Female; Gender; Heart rate; Humans; Intravenous administration; Intravenous infusion; Joint surgery; Ketorolac - administration & dosage; Ketorolac - standards; Ketorolac - therapeutic use; Kidneys; Magnesium sulfate; Magnesium Sulfate - administration & dosage; Magnesium Sulfate - standards; Magnesium Sulfate - therapeutic use; Magnesium sulphate; Male; Middle Aged; Muscle contraction; Muscles; Narcotics; Nerve endings; Pain; Pain - drug therapy; Pain management; Pain Management - methods; Pain Management - standards; Pain Management - statistics & numerical data; Patients; Renal colic; Renal Colic - complications; Renal Colic - drug therapy; Sedation; Statistical analysis; Statistics, Nonparametric; Sulfates; Ureter; Urogenital system; Iran; Sedation; Magnesium sulphate; Pain management; Renal colic
• ISSN: 0735-6757; 1532-8171
• DOI: 10.1016/j.ajem.2018.08.040

Ureter muscles contraction movements caused pain in renal colic. Magnesium sulphate could influence the pain by reducing acetylcholine in the nerve terminals. We have aimed to evaluate the analgesic effects of magnesium sulphate on acute renal colic pain. In this double-blind clinical trial study, the patients with renal colic pain were randomly divided into 2 groups; Group I received an intravenous infusion of 30 mg of Ketorolac and normal saline as placebo, Group II 50 mg/kg magnesium sulphate 50%/100 ml normal plus 30 mg of Ketorolac. The pain severity of patients was assessed using the visual analog scale (VAS) at baseline, and 15 and 30 min after intervention. Baseline pain score and demographic characteristics did not significantly different between the groups. After 30 min the pain score significantly reduced in both groups. While, at 15 and 30 min, mean pain score did not show statistically significant differences. Our findings indicated that Magnesium sulphate did not influence renal colic pain relief.