Antiglycation potential and antioxidant activity of genipap ( Genipa americana L.) in oxidative stress mediated by hydrogen peroxide on cell culture

• Published in: Natural product research Vol. 37; no. 12; pp. 2065 - 2069
• Main Authors: Santos, Aline Costa, Otsuka, Felipe Akihiro Melo, Santos, Rodrigo Brito, Trindade, Danielle de Jesus, Matos, Humberto Reis
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis Ltd 01.06.2023
• Subjects: Antioxidants; Antioxidants - chemistry; Antioxidants - pharmacology; Cell culture; Cell Culture Techniques; Cinnamic acid; Fruit juices; Genipa americana; Hydrogen peroxide; Hydrogen Peroxide - chemistry; Hydrogen Peroxide - pharmacology; Liquid chromatography; Medicinal plants; Oxidative Stress; Phenolic compounds; Phenols; Plant Extracts - chemistry; Plant Extracts - pharmacology; cinnamic acid; anti-glycation; Genipa americana L; antioxidant activity
• ISSN: 1478-6419; 1478-6427
• DOI: 10.1080/14786419.2022.2116700

is a plant widely used by folk medicine for the prevention and as an aid in the treatment of various diseases. In this work, we evaluated the anti-glycant and antioxidant activities of genipap fruit juice, as well as the influence of different temperatures (-6 °C and -80 °C) on the preservation of phenolic compounds. Purified extract from showed anti-glycant activity reducing the formation of fructosamine by up to 53% and recovered viability of cells under oxidative stress induced by H O . HPLC/UV-Vis analysis identified cinnamic acid as a bioactive substance and possibly responsible for the biological activities described above. Taken together, these results indicate that is a rich source of cinnamic acid with appreciable antioxidant and anti-glycant potential.