Trovafloxacin compared with levofloxacin, ofloxacin, ciprofloxacin, azithromycin and clarithromycin against unusual aerobic and anaerobic human and animal bite-wound pathogens

• Published in: Journal of antimicrobial chemotherapy Vol. 41; no. 3; pp. 391 - 396
• Main Authors: GOLDSTEIN, E. J. C, CITRON, D. M, HUDSPETH, M, GERARDO, S. H, MERRIAM, C. V
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.03.1998
• Subjects: Animals; Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacology; Antibacterial agents; Antibiotics. Antiinfectious agents. Antiparasitic agents; Azithromycin - administration & dosage; Azithromycin - pharmacology; Bacteria, Aerobic - drug effects; Bacteria, Aerobic - isolation & purification; Bacteria, Anaerobic - drug effects; Bacteria, Anaerobic - isolation & purification; Bacterial Infections - drug therapy; Bacterial Infections - microbiology; Biological and medical sciences; Bites and Stings - drug therapy; Bites and Stings - microbiology; Bites, Human - drug therapy; Bites, Human - microbiology; Ciprofloxacin - administration & dosage; Ciprofloxacin - pharmacology; Dose-Response Relationship, Drug; Drug Resistance, Microbial; Drug Resistance, Multiple; Fluoroquinolones; Humans; Levofloxacin; Medical sciences; Microbial Sensitivity Tests; Naphthyridines - administration & dosage; Naphthyridines - pharmacology; Ofloxacin - administration & dosage; Ofloxacin - pharmacology; Pharmacology. Drug treatments; Species Specificity; Wound Infection - drug therapy; Wound Infection - microbiology; Human; Levofloxacin; Clarithromycin; Trovafloxacin; Azithromycin; Ofloxacin; In vitro; Macrolide; Wound; Biological activity; Infection; Antibiotic; Fluoroquinolone derivatives; Animal; Minimum inhibitory concentration; Bacteria; Antibacterial agent; Ciprofloxacin; Comparative study; Quinolone derivatives
• ISSN: 0305-7453; 1460-2091
• DOI: 10.1093/jac/41.3.391

The activity of trovafloxacin and five other oral agents against 250 aerobic and 137 anaerobic strains isolated from human and animal bite wounds was determined by an agar dilution method. Trovafloxacin was active against all aerobic and fastidious facultative isolates at < or = 0.5 mg/L and all anaerobes at < or = 2 mg/L (Bacteroides tectum, Porphyromonas salivosa and Prevotella heparinolytica, < or = 0.25 mg/L; Porphyromonas spp., < or = 0.5 mg/L; Prevotella spp. and peptostreptococci, < or = 2.0 mg/L), except Fusobacterium nucleatum and other fusobacteria (MIC90 < or = 4 mg/L). Levofloxacin was generally one to two dilutions more active than ofloxacin, while ciprofloxacin was active against aerobes (MIC < or = 1 mg/L) but less active against anaerobic strains (MIC90 < or = 16 mg/L).