New pyridocarbazole alkaloids from Strychnos nitida

Phytochemical investigation of Strychnos nitida has led to the isolation of three new racemic pyridocarbazole alkaloids, (±)-stritidas A-C (1-3) and three known monoterpenoid indole alkaloids (4-6). Compounds 2 and 3 represent the first examples of pyridocarbazole alkaloids featuring an N-2-hydroxye...

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Published inNatural product research Vol. 32; no. 13; pp. 1532 - 1536
Main Authors Li, Wei, Tang, Gui-Hua, Chen, Lin, Tang, Ya-Qi, Xu, You-Kai, Liu, Bo, Yin, Sheng
Format Journal Article
LanguageEnglish
Published England Taylor & Francis Ltd 01.07.2018
Subjects
Alkaloids
Alkaloids - chemistry
Carbazoles - chemistry
Indoles
Magnetic Resonance Spectroscopy
Molecular Structure
NMR
Nuclear magnetic resonance
Secologanin Tryptamine Alkaloids - chemistry
Spectrometry, Mass, Electrospray Ionization
Spectrophotometry, Ultraviolet
Stereoisomerism
Strychnos
Strychnos - chemistry
pridocarbazole alkaloids
Strychnos nitida
monoterpenoid indole alkaloids
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Summary:Phytochemical investigation of Strychnos nitida has led to the isolation of three new racemic pyridocarbazole alkaloids, (±)-stritidas A-C (1-3) and three known monoterpenoid indole alkaloids (4-6). Compounds 2 and 3 represent the first examples of pyridocarbazole alkaloids featuring an N-2-hydroxyethyl moiety. Their structures were determined by combined spectroscopic data (MS, UV, IR and NMR) and chemical methods.
Bibliography:ObjectType-Article-1
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ISSN:1478-6419
1478-6427
DOI:10.1080/14786419.2017.1385016