l-Alanine induced thermally stable self-healing guar gum hydrogel as potential drug vehicle for sustained release of hydrophilic drug

A simple approach for preparing self-healable guar gum-graft-acrylic acid (GG-PAA) hydrogel using l-alanine as a cross-linking agent was introduced for the first time. It drastically modifies the mechanical strength of the hydrogel to G′ = 90,570 Pa. Thus, a series of guar gum (GG) based hydrogel wa...

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Published inMaterials Science & Engineering C Vol. 99; pp. 1384 - 1391
Main Authors Sharma, Swati, Afgan, Shere, Deepak, Kumar, Ashok, Kumar, Rajesh
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.06.2019
Elsevier BV
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Summary:A simple approach for preparing self-healable guar gum-graft-acrylic acid (GG-PAA) hydrogel using l-alanine as a cross-linking agent was introduced for the first time. It drastically modifies the mechanical strength of the hydrogel to G′ = 90,570 Pa. Thus, a series of guar gum (GG) based hydrogel was synthesized by varying the concentration of l-alanine from 0.4 to 1% w/v. The hydrogel was characterized by different analytical techniques such as FTIR, HRSEM etc. The mechanical strength of the hydrogel was investigated by rheology analysis and it was observed in terms of storage and loss modulus i.e. G′ & G′′, respectively. Maximum G′ & G′′ (90,560 Pa & 60,820 Pa) were observed when 1 wt% of l-alanine was used as a cross-linking agent. This GG based hydrogel have shown excellent swelling i.e. up to 3350%, which indicates its porous network. The synthesized hydrogel has been identified as a controlled drug delivery gel, which releases 98% of the highly water-soluble loaded drug in 140 h. A Guar gum based rapid self-healing hydrogel through in situ free radical polymerization has been synthesized. Prepared hydrogel showed appreciable swelling in different pH. It showed excellent rapid self-healing property without any external source with mangnify mechanical strength. Synthesized hydrogel is thermally stable upto 90 °C. Along with self-healing property it showed sustained release of hydrophilic levofloxacin.These properties turns GG based hydrogel as a potential candidate for drug delivery in biomedical application. [Display omitted] •Self-healing hydrogel was developed in aqueous medium via in-situ free radical polymerization.•This hydrogel was stable up to 90 °C, confirmed by temperature sweep study where storage and loss modulus were constant.•The hydrogel exhibited storage modulus up to 106000 Pa, confirms mechanically strong hydrogel.•The strain amplitude was 1500% which enables the hydrogel to be used as drug delivery vehicle.•This hydrogel exhibited excellent self-healing and viscoelastic properties.•The hydrogel showed prolong sustained release of highly water soluble levofloxacin drug at pH-7.4 & 37 °C up to 130 h.
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ISSN:0928-4931
1873-0191
DOI:10.1016/j.msec.2019.02.074