Evaluation of Xpert MTB/RIF for Detection of Mycobacterium tuberculosis in Cerebrospinal Fluid

Studies investigating Xpert MTB/RIF diagnostic performance on cerebrospinal fluid (CSF) samples are lacking in resource-rich settings. Xpert MTB/RIF results for 740 CSF samples from 698 patients across England were retrospectively compared with the results of culture of the same and contemporary sam...

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Published inJournal of clinical microbiology Vol. 54; no. 3; pp. 809 - 811
Main Authors Pink, F., Brown, T. J., Kranzer, K., Drobniewski, F.
Format Journal Article
LanguageEnglish
Published United States American Society for Microbiology 01.03.2016
Subjects
Adolescent
Adult
Aged
Aged, 80 and over
Cerebrospinal Fluid - microbiology
Child
Child, Preschool
Drug Resistance, Bacterial
Female
Humans
Infant
Infant, Newborn
Male
Middle Aged
Molecular Diagnostic Techniques
Mycobacteriology and Aerobic Actinomycetes
Mycobacterium tuberculosis - drug effects
Mycobacterium tuberculosis - genetics
Reagent Kits, Diagnostic
Rifampin - pharmacology
Sensitivity and Specificity
Tuberculosis, Central Nervous System - diagnosis
Tuberculosis, Central Nervous System - microbiology
Young Adult
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Summary:Studies investigating Xpert MTB/RIF diagnostic performance on cerebrospinal fluid (CSF) samples are lacking in resource-rich settings. Xpert MTB/RIF results for 740 CSF samples from 698 patients across England were retrospectively compared with the results of culture of the same and contemporary samples. The overall sensitivity was calculated at 55%.
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Citation Pink F, Brown TJ, Kranzer K, Drobniewski F. 2016. Evaluation of Xpert MTB/RIF for detection of Mycobacterium tuberculosis in cerebrospinal fluid. J Clin Microbiol 54:809–811. doi:10.1128/JCM.02806-15.
ISSN:0095-1137
1098-660X
1098-660X
DOI:10.1128/JCM.02806-15