Novel inhibitors of the hepatitis C virus NS3 proteinase
The hepatitis C virus proteinase inhibitor 4-methyl-1-(phenylmethyl)-2,6-pyridinedione 1 undergoes a novel autoxidation process, on silica gel, leading to the dimer 2 as the major product, a relatively more potent inhibitor of the enzyme.
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| Published in | Bioorganic & medicinal chemistry letters Vol. 15; no. 19; pp. 4275 - 4278 |
|---|---|
| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Oxford
Elsevier Ltd
01.10.2005
Elsevier |
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| Abstract | The hepatitis C virus proteinase inhibitor 4-methyl-1-(phenylmethyl)-2,6-pyridinedione
1 undergoes a novel autoxidation process, on silica gel, leading to the dimer
2 as the major product, a relatively more potent inhibitor of the enzyme. |
|---|---|
| AbstractList | The hepatitis C virus proteinase inhibitor 4-methyl-1-(phenylmethyl)-2,6-pyridinedione
1 undergoes a novel autoxidation process, on silica gel, leading to the dimer
2 as the major product, a relatively more potent inhibitor of the enzyme. The hepatitis C virus proteinase inhibitor 4-methyl-1-(phenylmethyl)-2,6-pyridinedione 1 undergoes a novel autoxidation process, on silica gel, leading to the dimer 2 as the major product, a relatively more potent inhibitor of the enzyme.The hepatitis C virus proteinase inhibitor 4-methyl-1-(phenylmethyl)-2,6-pyridinedione 1 undergoes a novel autoxidation process, on silica gel, leading to the dimer 2 as the major product, a relatively more potent inhibitor of the enzyme. The hepatitis C virus proteinase inhibitor 4-methyl-1-(phenylmethyl)-2,6-pyridinedione 1 undergoes a novel autoxidation process, on silica gel, leading to the dimer 2 as the major product, a relatively more potent inhibitor of the enzyme. |
| Author | Liu, Yi-Tsung Njoroge, F. George Saksena, Anil K. Bennett, Frank Dasmahapatra, Bimalendu Yang, Xiaozheng Arasappan, Ashok Pichardo, John S. Patel, Naginbhai M. Huang, Yuhua Butkiewicz, Nancy |
| Author_xml | – sequence: 1 givenname: Frank surname: Bennett fullname: Bennett, Frank email: frank.bennett@spcorp.com – sequence: 2 givenname: Yi-Tsung surname: Liu fullname: Liu, Yi-Tsung – sequence: 3 givenname: Anil K. surname: Saksena fullname: Saksena, Anil K. – sequence: 4 givenname: Ashok surname: Arasappan fullname: Arasappan, Ashok – sequence: 5 givenname: Nancy surname: Butkiewicz fullname: Butkiewicz, Nancy – sequence: 6 givenname: Bimalendu surname: Dasmahapatra fullname: Dasmahapatra, Bimalendu – sequence: 7 givenname: John S. surname: Pichardo fullname: Pichardo, John S. – sequence: 8 givenname: F. George surname: Njoroge fullname: Njoroge, F. George – sequence: 9 givenname: Naginbhai M. surname: Patel fullname: Patel, Naginbhai M. – sequence: 10 givenname: Yuhua surname: Huang fullname: Huang, Yuhua – sequence: 11 givenname: Xiaozheng surname: Yang fullname: Yang, Xiaozheng |
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| Keywords | Hepatitis Proteinase Enzyme Enzyme inhibitor In vitro Biological activity Pyridine derivatives Virus Autoxidation Peptidases Hydrolases Antiviral Dimer Silica gel Flaviviridae Chemical synthesis Hepatitis C virus Hepacivirus Protease inhibitor |
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| SubjectTerms | Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral agents Antiviral Agents - chemical synthesis Antiviral Agents - pharmacology Biological and medical sciences Dimerization Hepatitis Hepatitis C - enzymology Inhibitory Concentration 50 Medical sciences Oxidation-Reduction Pharmacology. Drug treatments Proteinase Pyridines - chemistry Serine Proteinase Inhibitors - chemical synthesis Serine Proteinase Inhibitors - pharmacology Structure-Activity Relationship Viral Nonstructural Proteins - antagonists & inhibitors |
| Title | Novel inhibitors of the hepatitis C virus NS3 proteinase |
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