Novel inhibitors of the hepatitis C virus NS3 proteinase

The hepatitis C virus proteinase inhibitor 4-methyl-1-(phenylmethyl)-2,6-pyridinedione 1 undergoes a novel autoxidation process, on silica gel, leading to the dimer 2 as the major product, a relatively more potent inhibitor of the enzyme.

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Bibliographic Details
Published inBioorganic & medicinal chemistry letters Vol. 15; no. 19; pp. 4275 - 4278
Main Authors Bennett, Frank, Liu, Yi-Tsung, Saksena, Anil K., Arasappan, Ashok, Butkiewicz, Nancy, Dasmahapatra, Bimalendu, Pichardo, John S., Njoroge, F. George, Patel, Naginbhai M., Huang, Yuhua, Yang, Xiaozheng
Format Journal Article
LanguageEnglish
Published Oxford Elsevier Ltd 01.10.2005
Elsevier
Subjects
Antibiotics. Antiinfectious agents. Antiparasitic agents
Antiviral agents
Antiviral Agents - chemical synthesis
Antiviral Agents - pharmacology
Biological and medical sciences
Dimerization
Hepatitis
Hepatitis C - enzymology
Inhibitory Concentration 50
Medical sciences
Oxidation-Reduction
Pharmacology. Drug treatments
Proteinase
Pyridines - chemistry
Serine Proteinase Inhibitors - chemical synthesis
Serine Proteinase Inhibitors - pharmacology
Structure-Activity Relationship
Viral Nonstructural Proteins - antagonists & inhibitors
Hepatitis
Proteinase
Enzyme
Enzyme inhibitor
In vitro
Biological activity
Pyridine derivatives
Virus
Autoxidation
Peptidases
Hydrolases
Antiviral
Dimer
Silica gel
Flaviviridae
Chemical synthesis
Hepatitis C virus
Hepacivirus
Protease inhibitor
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Summary:The hepatitis C virus proteinase inhibitor 4-methyl-1-(phenylmethyl)-2,6-pyridinedione 1 undergoes a novel autoxidation process, on silica gel, leading to the dimer 2 as the major product, a relatively more potent inhibitor of the enzyme.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0960-894X
1464-3405
DOI:10.1016/j.bmcl.2005.06.079