Electrospun Chitosan/Poly (Vinyl Alcohol)/Graphene Oxide Nanofibrous Membrane with Ciprofloxacin Antibiotic Drug for Potential Wound Dressing Application

In this paper, nanofibrous membranes based on chitosan (CS), poly (vinyl alcohol) (PVA) and graphene oxide (GO) composites, loaded with antibiotic drugs, such as Ciprofloxacin (Cip) and Ciprofloxacin hydrochloride (CipHcl) were prepared via the electrospinning technique. The uniform and defect-free...

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Bibliographic Details
Published inInternational journal of molecular sciences Vol. 20; no. 18; p. 4395
Main Authors Yang, Shuai, Zhang, Xiaohong, Zhang, Dawei
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 06.09.2019
MDPI
Subjects
Adsorption
Alcohol
antibacterial activity
Antibiotics
Antimicrobial agents
Biocompatibility
Cell adhesion & migration
Chemical compounds
Chitosan
Ciprofloxacin
composite nanofibrous membranes
Contact angle
cytocompatibility
Cytotoxicity
Drug delivery
Drug delivery systems
Drugs
Electrospinning
Fluorescence
Fourier transforms
Graphene
graphene oxide
Hydrogen bonds
Infrared spectroscopy
Membranes
Nanofibers
Pharmacology
regulatable drug-release profile
Scanning electron microscopy
Spectrum analysis
Wound healing
X-ray diffraction
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Summary:In this paper, nanofibrous membranes based on chitosan (CS), poly (vinyl alcohol) (PVA) and graphene oxide (GO) composites, loaded with antibiotic drugs, such as Ciprofloxacin (Cip) and Ciprofloxacin hydrochloride (CipHcl) were prepared via the electrospinning technique. The uniform and defect-free CS/PVA nanofibers were obtained and GO nanosheets, shaping spindle and spherical, were partially embedded into nanofibers. Besides, the antibiotic drugs were effectively loaded into the nanofibers and part of which were absorbed into GO nanosheets. Intriguingly, the release of the drug absorbed in GO nanosheets regulated the drug release profile trend, avoiding the “burst” release of drug at the release initial stage, and the addition of GO slightly improved the drug release ratio. Nanofibrous membranes showed the significantly enhanced antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis after the addition of antibiotic drug. Moreover, the drug-loaded nanofibrous membranes exhibited excellent cytocompatibility with Melanoma cells, indicative to the great potential potential for applications in wound dressing.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms20184395