Metabolism and excretion of (14C) verruculogen in a sheep

[14C] Verruculogen (75 micrograms/kg) was given intravenously to a sheep under barbiturate anaesthesia to prevent the severe tremor and convulsions which would otherwise have occurred. Two hours later 28 per cent of the tremorgenic mycotoxin was detected in the liver, bile and small intestine. Appro...

Full description

Saved in:
Bibliographic Details
Published inResearch in veterinary science Vol. 32; no. 3; pp. 347 - 350
Main Authors Perera, K.P.W.C, Mantle, P.G, Penny, R.H.C
Format Journal Article
LanguageEnglish
Published England 01.05.1982
Subjects
Animals
Bile - analysis
Brain - metabolism
carbon
Chromatography, High Pressure Liquid
Ileum - metabolism
Indoles - metabolism
isotopes
Liver - metabolism
Male
Mycotoxins - metabolism
radionuclides
Sheep - metabolism
Online AccessGet more information

Cover

More Information
Summary:[14C] Verruculogen (75 micrograms/kg) was given intravenously to a sheep under barbiturate anaesthesia to prevent the severe tremor and convulsions which would otherwise have occurred. Two hours later 28 per cent of the tremorgenic mycotoxin was detected in the liver, bile and small intestine. Approximately 0.5 per cent was excreted in the urine. Trace amounts of radiolabel were detected in the cortex and corpus striatum of the brain. Verruculogen was metabolised by the liver and converted completely to four more polar products, including two isomeric forms of desoxy-verruculogen and the weakly tremorgenic mycotoxin TR-2. The principal and most polar metabolite excreted is probably an isomer of TR-2.
ISSN:0034-5288
1532-2661
DOI:10.1016/S0034-5288(18)32393-2