Cerium oxide nanoparticle-containing poly (ε-caprolactone)/gelatin electrospun film as a potential wound dressing material: In vitro and in vivo evaluation

• Published in: Materials Science & Engineering C Vol. 81; pp. 366 - 372
• Main Authors: Naseri-Nosar, Mahdi, Farzamfar, Saeed, Sahrapeyma, Hamed, Ghorbani, Sadegh, Bastami, Farshid, Vaez, Ahmad, Salehi, Majid
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.12.2017; Elsevier BV
• Subjects: Animals; Bandages; Cerium; Cerium oxide; Cerium oxides; Contact angle; Electrospinning; Gauze; Gelatin; In vivo methods and tests; Materials science; Medical dressings; Metal Nanoparticles; Morphology; Nanoparticles; Poly (ε-caprolactone); Polyesters; Rats; Water vapor; Wound dressing; Wound Healing; Wounds; Electrospinning; Poly (ε-caprolactone); Wound dressing; Cerium oxide; Gelatin
• ISSN: 0928-4931; 1873-0191
• DOI: 10.1016/j.msec.2017.08.013

In the present study, cerium oxide (CeO2) nanoparticles were incorporated into poly (ε-caprolactone)/gelatin films in order to develop a potential wound dressing material. The wound dressings were prepared by electrospinning of poly (ε-caprolactone)/gelatin (1:1 (w/w)) solutions containing 1.50%, 3% and 6% (w/w) CeO2 nanoparticles. The electrospun films were evaluated regarding their morphology, contact angle, water-uptake capacity, water vapor transmission rate, tensile strength and cellular response. The film containing 1.50% CeO2 nanoparticles was chosen as the optimal dressing for the in vivo study on full-thickness excisional wounds of rats. The study showed that after 2weeks, the wounds treated with the CeO2 nanoparticle-containing dressing achieved a significant closure to nearly 100% compared with the sterile gauze with the nearly 63% of wound closure. Our results provided evidence supporting the possible applicability of CeO2 nanoparticle-containing wound dressing for a successful wound treatment. •Production of a cerium oxide nanoparticles-containing PCL/gelatin wound dressing.•Evaluation of the produced wound dressing.•Achieving an almost complete wound closure by treating the rat's full-thickness excisional wounds with the produced wound dressing for two weeks.