Differential diagnosis of human bladder mucosa pathologies in vivo with cross-polarization optical coherence tomography

• Published in: Biomedical optics express Vol. 6; no. 4; pp. 1464 - 1476
• Main Authors: Kiseleva, Elena, Kirillin, Mikhail, Feldchtein, Felix, Vitkin, Alex, Sergeeva, Ekaterina, Zagaynova, Elena, Streltzova, Olga, Shakhov, Boris, Gubarkova, Ekaterina, Gladkova, Natalia
• Format: Journal Article
• Language: English
• Published: United States Optical Society of America 01.04.2015
• Subjects: (170.1610) Clinical applications; (170.7230) Urology; (100.2960) Image analysis; (290.5855) Scattering, polarization; (110.4500) Optical coherence tomography; (230.5440) Polarization-selective devices
• ISSN: 2156-7085; 2156-7085
• DOI: 10.1364/BOE.6.001464

Quantitative image analysis and parameter extraction using a specific implementation of polarization-sensitive optical coherence tomography (OCT) provides differential diagnosis of mucosal pathologies in in-vivo human bladders. We introduce a cross-polarization (CP) OCT image metric called Integral Depolarization Factor (IDF) to enable automatic diagnosis of bladder conditions (assessment the functional state of collagen fibers). IDF-based diagnostic accuracy of identification of the severe fibrosis of normal bladder mucosa is 79%; recurrence of carcinoma on the post-operative scar is 97%; and differentiation between neoplasia and acute inflammation is 75%. The promising potential of CP OCT combined with image analysis in human urology is thus demonstrated in vivo.