Hemophagocytic Lymphohistiocytosis Related to Tuberculosis Disease

Hemophagocytic lymphohistiocytosis (HLH) is a rare, albeit potentially fatal, condition in which fever, hepatosplenomegaly, and cytopenia predominate the clinical picture. Although it may be primary, it may also develop secondary to various etiologies. Herein, we aimed to report a patient who was di...

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Bibliographic Details
Published inIndian journal of critical care medicine Vol. 24; no. 1; pp. 63 - 65
Main Authors Erdoğan, Seher, Çakır, Deniz, Bozkurt, Tuğçe, Karakayalı, Burcu, Kalın, Sevinç, Koç, Begüm, Sözeri, Betül
Format Journal Article
LanguageEnglish
Published India Jaypee Brothers Medical Publishers 01.01.2020
Subjects
Case Report
Hemophagocytic lymphohistiocytosis
Tuberculosis
Therapeutic plasma exchange
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Summary:Hemophagocytic lymphohistiocytosis (HLH) is a rare, albeit potentially fatal, condition in which fever, hepatosplenomegaly, and cytopenia predominate the clinical picture. Although it may be primary, it may also develop secondary to various etiologies. Herein, we aimed to report a patient who was diagnosed with pulmonary tuberculosis, developed fever and cytopenia during follow-up, and received immunomodulatory therapy together with antituberculosis therapy for the diagnosis of HLH. Sequencing of PRF1 showed heterozygous mutation. Although primary HLH has been detected in infants and children, genetic mutation of genes should be considered a differential diagnosis of HLH even in the adolescent. Erdoğan S, Çakır D, Bozkurt T, Karakayalı B, Kalın S, Koç B, Hemophagocytic Lymphohistiocytosis Related to Tuberculosis Disease. Indian J Crit Care Med 2020;24(1):63-65.
ISSN:0972-5229
1998-359X
DOI:10.5005/jp-journals-10071-23329