One-stage anterior approach for four-vessel occlusion in rat

We report a modified 4-vessel occlusion (4VO) rat model. We used a 1-stage anterior approach for making bilateral hemispheric ischemia. Modified 4VO method decreased cerebral blood flow to 12% to 14% of baseline levels. This modified 4VO method is a minimally invasive, quick, reliable procedure for...

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Bibliographic Details
Published inStroke (1970) Vol. 36; no. 10; pp. 2212 - 2214
Main Authors YAMAGUCHI, Mitsuo, CALVERT, John W, KUSAKA, Gen, ZHANG, John H
Format Journal Article
LanguageEnglish
Published Hagerstown, MD Lippincott Williams & Wilkins 01.10.2005
Subjects
Animals
Antihypertensive agents
Biological and medical sciences
Brain - anatomy & histology
Brain Ischemia - pathology
Cardiovascular system
Cerebrovascular Circulation
Disease Models, Animal
Male
Medical sciences
Models, Anatomic
Neurology
Neuropharmacology
Neuroprotective agent
Pharmacology. Drug treatments
Rats
Rats, Sprague-Dawley
Vascular diseases and vascular malformations of the nervous system
Stroke
Nervous system diseases
Rat
Rodentia
Cardiovascular disease
Cerebral disorder
Blood flow
Vascular disease
Vertebrata
Mammalia
cerebral ischemia, global
Ischemia
Animal
Central nervous system disease
cerebral blood flow
Cerebrovascular disease
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Summary:We report a modified 4-vessel occlusion (4VO) rat model. We used a 1-stage anterior approach for making bilateral hemispheric ischemia. Modified 4VO method decreased cerebral blood flow to 12% to 14% of baseline levels. This modified 4VO method is a minimally invasive, quick, reliable procedure for producing ischemic changes.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0039-2499
1524-4628
DOI:10.1161/01.STR.0000182238.08510.c5