Platelet aggregation and dense granule secretion in a colony of dogs with spontaneous hypertension

• Published in: Journal of hypertension Vol. 10; no. 12; p. 1493
• Main Authors: Thomas, J S, McConnell, M F, Bell, T G, Padgett, G A
• Format: Journal Article
• Language: English
• Published: England 01.12.1992
• Subjects: Adenosine Triphosphate - metabolism; Animals; Blood Platelets - metabolism; Case-Control Studies; Cytoplasmic Granules - metabolism; Dogs; Female; Hypertension - physiopathology; Male; Platelet Aggregation
• ISSN: 0263-6352
• DOI: 10.1097/00004872-199210120-00009

Since canine hereditary essential hypertension has been previously reported in a colony of Siberian husky dogs, we tested the suitability of this model for use in studies on the platelet defect identified in humans with essential hypertension. Platelet aggregation and dense granule ATP secretion were measured in dogs with essential hypertension and normotensive control dogs. The platelets from the hypertensive group showed significantly increased aggregation and secretion in response to stimulation with ADP. There was no significant increase in aggregation or secretion when platelets from hypertensive dogs were stimulated by platelet-activating factor, thrombin, calcium ionophore A23187 or phorbol myristate acetate. The increased aggregation and secretion responses in platelets from the hypertensive dogs suggest that a defect similar to that reported in humans with essential hypertension exists and that further investigation is warranted.