Synthetic Studies on an Antitumor Antibiotic, Bleomycin. XII. Preparation of an L-2, 3-Diaminopropionic Acid Derivative as a Synthetic Intermediate

Three methods have been developed for the preparation of (S)-3-amino-2-tert-butoxycar-bonylaminopropionamide suitably protected for use in the total synthesis of bleomycin.

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 33; no. 2; pp. 509 - 514
Main Authors YAMASHITA, HARUO, KITTAKA, ATSUSHI, IIMORI, TAKAMASA, OTSUKA, MASAMI, OHNO, MASAJI, KOBAYASHI, SUSUMU
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 1985
公益社団法人日本薬学会
Maruzen
Subjects
(S)-3-amino-2-tert-butoxycarbonylaminopropionamide
Alanine - analogs & derivatives
Aliphatic compounds
beta-Alanine - analogs & derivatives
beta-Alanine - chemical synthesis
bleomycin
Bleomycin - chemical synthesis
Chemical Phenomena
Chemistry
Exact sciences and technology
Hofmann rearrangement
L-2, 3-diaminopropionic acid
L-asparagine
L-serine
Mitsunobu reaction
Organic chemistry
Preparations and properties
Diamine
Antibiotic
Aminoamide
Aliphatic compound
Aminoacid
Saturated compound
Hofmann reaction
Online AccessGet full text
ISSN0009-2363
1347-5223
DOI10.1248/cpb.33.509

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Summary:Three methods have been developed for the preparation of (S)-3-amino-2-tert-butoxycar-bonylaminopropionamide suitably protected for use in the total synthesis of bleomycin.
Bibliography:ObjectType-Article-1
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content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.33.509