Effect of high‐intensity training on bone health and body composition in lung transplant recipients: A secondary analysis of a randomized controlled trial
Background Loss of bone mineral and skeletal muscle mass is common after lung transplantation (LTx), and physical activity (PA) may prevent further deterioration. We aimed to assess the effects of 20‐week high‐intensity training (HIT) on body composition, bone health, and PA in LTx recipients, 6–60 ...
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Published in | Clinical transplantation Vol. 35; no. 8; pp. e14375 - n/a |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English Norwegian |
Published |
Denmark
01.08.2021
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Subjects | |
Online Access | Get full text |
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Summary: | Background
Loss of bone mineral and skeletal muscle mass is common after lung transplantation (LTx), and physical activity (PA) may prevent further deterioration. We aimed to assess the effects of 20‐week high‐intensity training (HIT) on body composition, bone health, and PA in LTx recipients, 6–60 months after surgery.
Methods
In a randomized controlled trial, 51 LTx recipients underwent Dual‐energy X‐ray absorptiometry (DXA), and PA level and sedentary time were objectively recorded by accelerometers for seven consecutive days. Of these, 39 participants completed the study, including 19 participants in the HIT group and 20 participants in the standard care group.
Results
Following the intervention, ANCOVA models revealed a nonsignificant between‐group difference for change in lean body mass (LBM) and bone mineral density (BMD) of the lumbar spine of 0.4% (95% CI = −3.2, 1.5) (p = .464) and 1.0% (95% CI=−1.3, 3.4) (p = .373), respectively. Trabecular bone score (TBS) of the lumbar spine (L1‐L4), however, increased by 2.2 ± 5.0% in the exercise group and decreased by −1.6 ± 5.9% in the control group, giving a between‐group difference of 3.8% (95% CI=0.1, 7.5) (p = .043). There were no between‐group differences in PA or sedentary time.
Conclusion
High‐intensity training after LTx improved TBS significantly, but not PA, LBM or BMD. |
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Bibliography: | Funding information The study was funded by research grants from the Division of Cardiovascular and Pulmonary Diseases at Oslo University Hospital and the Norwegian Respiratory Society ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-News-3 content type line 23 |
ISSN: | 0902-0063 1399-0012 |
DOI: | 10.1111/ctr.14375 |