Purification of carbon-11 PET radiotracers from unlabeled precursors by preparative HPLC and SPE

A general methodology for the rapid purification of carbon‐11 positron emission tomography (PET) radiotracers from radiolabeling reaction mixtures has been developed. Preparative HPLC and solid‐phase extraction (SPE) techniques are described which can separate some commonly used radiopharmaceuticals...

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Bibliographic Details
Published inBiomedical chromatography Vol. 19; no. 9; pp. 671 - 676
Main Authors Zheng, Qi-Huang, Mock, Bruce H.
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 01.11.2005
Subjects
Carbon Radioisotopes - chemistry
Carbon Radioisotopes - isolation & purification
carbon-11 radiotracer
Chemical Fractionation - methods
Choline - chemistry
Chromatography, High Pressure Liquid - methods
Cocaine - analogs & derivatives
Cocaine - chemistry
HPLC
Positron-Emission Tomography
Raclopride - chemistry
Radiopharmaceuticals - chemical synthesis
Radiopharmaceuticals - chemistry
Radiopharmaceuticals - isolation & purification
SPE
Online AccessGet full text
ISSN0269-3879
1099-0801
DOI10.1002/bmc.494

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Abstract A general methodology for the rapid purification of carbon‐11 positron emission tomography (PET) radiotracers from radiolabeling reaction mixtures has been developed. Preparative HPLC and solid‐phase extraction (SPE) techniques are described which can separate some commonly used radiopharmaceuticals such as [11C]raclopride, [11C]β‐CFT and [11C]choline from their unlabeled precursors. Copyright © 2005 John Wiley & Sons, Ltd.
AbstractList A general methodology for the rapid purification of carbon-11 positron emission tomography (PET) radiotracers from radiolabeling reaction mixtures has been developed. Preparative HPLC and solid-phase extraction (SPE) techniques are described which can separate some commonly used radiopharmaceuticals such as [(11)C]raclopride, [(11)C]beta-CFT and [(11)C]choline from their unlabeled precursors.
A general methodology for the rapid purification of carbon‐11 positron emission tomography (PET) radiotracers from radiolabeling reaction mixtures has been developed. Preparative HPLC and solid‐phase extraction (SPE) techniques are described which can separate some commonly used radiopharmaceuticals such as [11C]raclopride, [11C]β‐CFT and [11C]choline from their unlabeled precursors. Copyright © 2005 John Wiley & Sons, Ltd.
A general methodology for the rapid purification of carbon-11 positron emission tomography (PET) radiotracers from radiolabeling reaction mixtures has been developed. Preparative HPLC and solid-phase extraction (SPE) techniques are described which can separate some commonly used radiopharmaceuticals such as [(11)C]raclopride, [(11)C]beta-CFT and [(11)C]choline from their unlabeled precursors.A general methodology for the rapid purification of carbon-11 positron emission tomography (PET) radiotracers from radiolabeling reaction mixtures has been developed. Preparative HPLC and solid-phase extraction (SPE) techniques are described which can separate some commonly used radiopharmaceuticals such as [(11)C]raclopride, [(11)C]beta-CFT and [(11)C]choline from their unlabeled precursors.
A general methodology for the rapid purification of carbon-11 positron emission tomography (PET) radiotracers from radiolabeling reaction mixtures has been developed. Preparative HPLC and solid-phase extraction (SPE) techniques are described which can separate some commonly used radiopharmaceuticals such as [ super(11)C]raclopride, [ super(11)C][beta]-CFT and [ super(11)C]choline from their unlabeled precursors.
Author Zheng, Qi-Huang
Mock, Bruce H.
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  givenname: Qi-Huang
  surname: Zheng
  fullname: Zheng, Qi-Huang
  email: qzheng@iupui.edu
  organization: Department of Radiology, Indiana University School of Medicine, 1345 West 16th Street, L-3 Room 202, Indianapolis, IN 46202, USA
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  givenname: Bruce H.
  surname: Mock
  fullname: Mock, Bruce H.
  organization: Department of Radiology, Indiana University School of Medicine, 1345 West 16th Street, L-3 Room 202, Indianapolis, IN 46202, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/15803445$$D View this record in MEDLINE/PubMed
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References Zheng Q-H and Mulholland GK. Improved synthesis of β-CIT and [11C]β-CIT labeled at nitrogen or oxygen positions. Nuclear Medicine and Biology 1996; 23: 981.
Fei X, Mock BH, DeGrado TR, Wang J-Q, Glick-Wilson BE, Sullivan ML, Hutchins GD and Zheng Q-H. An improved synthesis of PET dopamine D2 receptors radioligand [11C]raclopride. Synthetic Communications 2004; 34: 1897.
Zheng Q-H, Stone KL, Mock BH, Miller KD, Fei X, Liu X, Wang J-Q, Glick-Wilson BE, Sledge GW and Hutchins GD. [11C]Choline as a potential PET marker for imaging of breast cancer athymic mice. Nuclear Medicine and Biology 2002; 29: 803.
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Hara T, Kosaka N and Kishi H. PET imaging of prostate cancer using carbon-11-choline. Journal of Nuclear Medicine 1998; 39: 990.
Weissleder R and Mahmood U. Molecular imaging. Radiology 2001; 219: 316.
Mock BH, Mulholland GK and Vavrek MT. Convenient gas phase bromination of [11C]methane and production of [11C]methyl triflate. Nuclear Medicine and Biology 1999; 26: 467.
Mulholland KM, Zheng Q-H, Mock BH and Vavrek MT. Convenient labeling and isolation of [11C-methyl]quaternary amines. Journal of Labeled Compounds and Radiopharmaceuticals 1999; 42(suppl. 1): S459.
Fowler JS, Volkow ND, Wang GJ, Ding YS and Dewey SL. PET and drug research and development. Journal of Nuclear Medicine 1999; 40: 1154.
Zheng Q-H, Gardner TA, Raikwar S, Kao C, Stone KL, Martinez TD, Mock BH, Fei X, Wang J-Q and Hutchins GD. [11C]Choline as a PET biomarker for assessment of prostate cancer tumor models. Bioorganic and Medicinal Chemistry 2004; 12: 2887.
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Jewett (10.1002/bmc.494-BIB5) 1992; 43
Hara (10.1002/bmc.494-BIB4) 1998; 39
Mock (10.1002/bmc.494-BIB6) 1999; 26
Mulholland (10.1002/bmc.494-BIB7) 1999; 42
Zheng (10.1002/bmc.494-BIB11) 2002; 29
Fowler (10.1002/bmc.494-BIB3) 1999; 40
Weissleder (10.1002/bmc.494-BIB8) 2001; 219
Zheng (10.1002/bmc.494-BIB10) 2004; 12
Zheng (10.1002/bmc.494-BIB9) 1996; 23
References_xml – reference: Mock BH, Mulholland GK and Vavrek MT. Convenient gas phase bromination of [11C]methane and production of [11C]methyl triflate. Nuclear Medicine and Biology 1999; 26: 467.
– reference: Fei X, Mock BH, DeGrado TR, Wang J-Q, Glick-Wilson BE, Sullivan ML, Hutchins GD and Zheng Q-H. An improved synthesis of PET dopamine D2 receptors radioligand [11C]raclopride. Synthetic Communications 2004; 34: 1897.
– reference: Mulholland KM, Zheng Q-H, Mock BH and Vavrek MT. Convenient labeling and isolation of [11C-methyl]quaternary amines. Journal of Labeled Compounds and Radiopharmaceuticals 1999; 42(suppl. 1): S459.
– reference: Fowler JS, Volkow ND, Wang GJ, Ding YS and Dewey SL. PET and drug research and development. Journal of Nuclear Medicine 1999; 40: 1154.
– reference: Hara T, Kosaka N and Kishi H. PET imaging of prostate cancer using carbon-11-choline. Journal of Nuclear Medicine 1998; 39: 990.
– reference: Weissleder R and Mahmood U. Molecular imaging. Radiology 2001; 219: 316.
– reference: Zheng Q-H, Stone KL, Mock BH, Miller KD, Fei X, Liu X, Wang J-Q, Glick-Wilson BE, Sledge GW and Hutchins GD. [11C]Choline as a potential PET marker for imaging of breast cancer athymic mice. Nuclear Medicine and Biology 2002; 29: 803.
– reference: Zheng Q-H and Mulholland GK. Improved synthesis of β-CIT and [11C]β-CIT labeled at nitrogen or oxygen positions. Nuclear Medicine and Biology 1996; 23: 981.
– reference: Jewett DM. A simple synthesis of [11C]methyl triflate. Applied Radiation and Isotopes 1992; 43: 1383.
– reference: Brashear A, Mulholland GK, Zheng Q-H, Farlow MR, Siemers ER and Hutchins GD. PET imaging of the pre-synaptic dopamine uptake sites in rapid-onset dystonia-parkinsonism (RDP). Movement Disorders 1999; 14: 132.
– reference: Zheng Q-H, Gardner TA, Raikwar S, Kao C, Stone KL, Martinez TD, Mock BH, Fei X, Wang J-Q and Hutchins GD. [11C]Choline as a PET biomarker for assessment of prostate cancer tumor models. Bioorganic and Medicinal Chemistry 2004; 12: 2887.
– volume: 23
  start-page: 981
  year: 1996
  article-title: Improved synthesis of ‐CIT and [ C] ‐CIT labeled at nitrogen or oxygen positions
  publication-title: Nuclear Medicine and Biology
– volume: 29
  start-page: 803
  year: 2002
  article-title: [ C]Choline as a potential PET marker for imaging of breast cancer athymic mice
  publication-title: Nuclear Medicine and Biology
– volume: 14
  start-page: 132
  year: 1999
  article-title: PET imaging of the pre‐synaptic dopamine uptake sites in rapid‐onset dystonia‐parkinsonism (RDP)
  publication-title: Movement Disorders
– volume: 34
  start-page: 1897
  year: 2004
  article-title: An improved synthesis of PET dopamine D2 receptors radioligand [ C]raclopride
  publication-title: Synthetic Communications
– volume: 40
  start-page: 1154
  year: 1999
  article-title: PET and drug research and development
  publication-title: Journal of Nuclear Medicine
– volume: 219
  start-page: 316
  year: 2001
  article-title: Molecular imaging
  publication-title: Radiology
– volume: 26
  start-page: 467
  year: 1999
  article-title: Convenient gas phase bromination of [ C]methane and production of [ C]methyl triflate
  publication-title: Nuclear Medicine and Biology
– volume: 43
  start-page: 1383
  year: 1992
  article-title: A simple synthesis of [ C]methyl triflate
  publication-title: Applied Radiation and Isotopes
– volume: 42
  start-page: S459
  issue: (suppl. 1)
  year: 1999
  article-title: Convenient labeling and isolation of [ C‐methyl]quaternary amines
  publication-title: Journal of Labeled Compounds and Radiopharmaceuticals
– volume: 39
  start-page: 990
  year: 1998
  article-title: PET imaging of prostate cancer using carbon‐11‐choline
  publication-title: Journal of Nuclear Medicine
– volume: 12
  start-page: 2887
  year: 2004
  article-title: [ C]Choline as a PET biomarker for assessment of prostate cancer tumor models
  publication-title: Bioorganic and Medicinal Chemistry
– volume: 43
  start-page: 1383
  year: 1992
  ident: 10.1002/bmc.494-BIB5
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Snippet A general methodology for the rapid purification of carbon‐11 positron emission tomography (PET) radiotracers from radiolabeling reaction mixtures has been...
A general methodology for the rapid purification of carbon-11 positron emission tomography (PET) radiotracers from radiolabeling reaction mixtures has been...
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SubjectTerms Carbon Radioisotopes - chemistry
Carbon Radioisotopes - isolation & purification
carbon-11 radiotracer
Chemical Fractionation - methods
Choline - chemistry
Chromatography, High Pressure Liquid - methods
Cocaine - analogs & derivatives
Cocaine - chemistry
HPLC
Positron-Emission Tomography
Raclopride - chemistry
Radiopharmaceuticals - chemical synthesis
Radiopharmaceuticals - chemistry
Radiopharmaceuticals - isolation & purification
SPE
Title Purification of carbon-11 PET radiotracers from unlabeled precursors by preparative HPLC and SPE
URI https://api.istex.fr/ark:/67375/WNG-2BZ9WPGB-J/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fbmc.494
https://www.ncbi.nlm.nih.gov/pubmed/15803445
https://www.proquest.com/docview/19433036
https://www.proquest.com/docview/68754487
Volume 19
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