Purification of carbon-11 PET radiotracers from unlabeled precursors by preparative HPLC and SPE

A general methodology for the rapid purification of carbon‐11 positron emission tomography (PET) radiotracers from radiolabeling reaction mixtures has been developed. Preparative HPLC and solid‐phase extraction (SPE) techniques are described which can separate some commonly used radiopharmaceuticals...

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Bibliographic Details
Published inBiomedical chromatography Vol. 19; no. 9; pp. 671 - 676
Main Authors Zheng, Qi-Huang, Mock, Bruce H.
Format Journal Article
LanguageEnglish
Published Chichester, UK John Wiley & Sons, Ltd 01.11.2005
Subjects
Carbon Radioisotopes - chemistry
Carbon Radioisotopes - isolation & purification
carbon-11 radiotracer
Chemical Fractionation - methods
Choline - chemistry
Chromatography, High Pressure Liquid - methods
Cocaine - analogs & derivatives
Cocaine - chemistry
HPLC
Positron-Emission Tomography
Raclopride - chemistry
Radiopharmaceuticals - chemical synthesis
Radiopharmaceuticals - chemistry
Radiopharmaceuticals - isolation & purification
SPE
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Summary:A general methodology for the rapid purification of carbon‐11 positron emission tomography (PET) radiotracers from radiolabeling reaction mixtures has been developed. Preparative HPLC and solid‐phase extraction (SPE) techniques are described which can separate some commonly used radiopharmaceuticals such as [11C]raclopride, [11C]β‐CFT and [11C]choline from their unlabeled precursors. Copyright © 2005 John Wiley & Sons, Ltd.
Bibliography:istex:85918419D6391BFD682C1F7D0FE7594C88D59D0C
ark:/67375/WNG-2BZ9WPGB-J
Susan G. Komen Breast Cancer Foundation - No. IMG 02-1550
ArticleID:BMC494
INGEN, Indiana University.
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ISSN:0269-3879
1099-0801
DOI:10.1002/bmc.494