Comparative Anatomy of the Male Guinea-Pig and Human Lower Urinary Tract: Histomorphology and Three-Dimensional Reconstruction
The guinea‐pig is often used for experimental studies in urology. However, the anatomy of the lower urinary tract of the guinea‐pig is poorly described in the literature. The structure and function of the lower urinary tract, i.e. continence, micturition and sexual function, are closely related to t...
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Published in | Anatomia, histologia, embryologia Vol. 30; no. 4; pp. 185 - 192 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Berlin, Germany
Blackwell Science Ltd
01.08.2001
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Subjects | |
Online Access | Get full text |
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Summary: | The guinea‐pig is often used for experimental studies in urology. However, the anatomy of the lower urinary tract of the guinea‐pig is poorly described in the literature. The structure and function of the lower urinary tract, i.e. continence, micturition and sexual function, are closely related to the gross anatomy of the pelvis and the fine structure of the musculature. We investigated the anatomy and histomorphology of the lower urinary tract by serial sections in male guinea‐pigs and compared it to that in humans. Immunohistochemical stainings for alpha‐smooth muscle cell actin were used to differentiate between smooth and striated muscles. By using whole pelvic preparations, including all internal organs preserved in their in situ location for three‐dimensional reconstruction, we developed three‐dimensional models, which elucidate the spatial relationship of all muscular structures and can help to deduce functional aspects of lower urinary tract function. In the guinea‐pig, most of the muscles found in humans can be demonstrated in comparable location and extension. However, the structure of the prostate and the existence of the so‐called coagulation glands define a significant difference in the morphology of the prostatic urethra. |
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Bibliography: | ark:/67375/WNG-6JWF2T1K-V ArticleID:AHE323 NEUHAUS, J., W. DORSCHNER, J. MONDRY and J.-U. STOLZENBURG: Comparative Anatomy of the Male Guinea-Pig and Human Lower Urinary Tract: Histomorphology and Three-Dimensional Reconstruction Anatomia, Histologia, Embryologia, 30, 185-192. The above paper is republished on the following pages due to quality issues. istex:8DD53A4AEF8949E4304E2EF1FF6B36AE665DE9A6 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Correction/Retraction-1 ObjectType-Feature-3 content type line 23 |
ISSN: | 0340-2096 1439-0264 |
DOI: | 10.1046/j.1439-0264.2001.00323.x |