Liposome formulation of NSC-639829 using halothane as a solvent: a technical note

Conclusion Halothane has been successfully used as a solvent for the liposome formulation of NSC-639829. Liposomes with similar morphology, particle size, incorporation efficiency, and stability were obtained with halothane, chloroform, and ether. Halothane provides additional ease in formulation be...

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Bibliographic Details
Published inAAPS PharmSciTech Vol. 4; no. 4; pp. E52 - 417
Main Authors Jain, Akash, Sanghvi, Tapan, Yalkowsky, Samuel H
Format Journal Article
LanguageEnglish
Published United States Springer-Verlag 01.12.2003
Subjects
Antineoplastic Agents - administration & dosage
Chemistry, Pharmaceutical
Drug Carriers
Drug Delivery Systems
Halothane - chemistry
Liposomes - administration & dosage
Pyrimidines - administration & dosage
Solvents
Urea - administration & dosage
Urea - analogs & derivatives
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Summary:Conclusion Halothane has been successfully used as a solvent for the liposome formulation of NSC-639829. Liposomes with similar morphology, particle size, incorporation efficiency, and stability were obtained with halothane, chloroform, and ether. Halothane provides additional ease in formulation because of its higher volatility and safety as compared with chloroform and ether. Halothane can be regarded as a safe alternative to chloroform or ether in liposome formulation.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
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ISSN:1530-9932
1530-9932
DOI:10.1208/pt040452