Onco-Ontogeny of Squamous Cell Cancer of the First Pharyngeal Arch Derivatives

• Published in: International journal of molecular sciences Vol. 25; no. 18; p. 9979
• Main Authors: Sat-Muñoz, Daniel, Balderas-Peña, Luz-Ma-Adriana, Gómez-Sánchez, Eduardo, Martínez-Herrera, Brenda-Eugenia, Trujillo-Hernández, Benjamín, Quiroga-Morales, Luis-Aarón, Salazar-Páramo, Mario, Dávalos-Rodríguez, Ingrid-Patricia, Nuño-Guzmán, Carlos M, Velázquez-Flores, Martha-Cecilia, Ochoa-Plascencia, Miguel-Ricardo, Muciño-Hernández, María-Ivette, Isiordia-Espinoza, Mario-Alberto, Mireles-Ramírez, Mario-Alberto, Hernández-Salazar, Eduardo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 16.09.2024; MDPI
• Subjects: Aging; Animals; BMP; Branchial Region - metabolism; Branchial Region - pathology; Cancer; Carcinogenesis; Carcinogenesis - genetics; Carcinogenesis - pathology; Carcinoma, Squamous Cell - genetics; Carcinoma, Squamous Cell - pathology; Development and progression; Embryology; Embryonic development; Embryos; Epigenetics; Gene expression; Gene Expression Regulation, Neoplastic; Genetic aspects; Genomes; Head and Neck Neoplasms - genetics; Head and Neck Neoplasms - pathology; head and neck squamous cell carcinoma; Health aspects; HOX; Human papillomavirus; Humans; Larynx; Metastasis; Morphogenesis; Mutation; notch; onco-ontogeny; Review; Signal Transduction; Squamous Cell Carcinoma of Head and Neck - genetics; Squamous Cell Carcinoma of Head and Neck - metabolism; Squamous Cell Carcinoma of Head and Neck - pathology; Stem cells; Surgeons; Throat cancer; Tumors; Mexico; HOX; onco-ontogeny; notch; BMP; head and neck squamous cell carcinoma
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms25189979

Head and neck squamous cell carcinoma (H&NSCC) is an anatomic, biological, and genetic complex disease. It involves more than 1000 genes implied in its oncogenesis; for this review, we limit our search and description to the genes implied in the onco-ontogeny of the derivates from the first pharyngeal arch during embryo development. They can be grouped as transcription factors and signaling molecules (that act as growth factors that bind to receptors). Finally, we propose the term embryo-oncogenesis to refer to the activation, reactivation, and use of the genes involved in the embryo's development during the oncogenesis or malignant tumor invasion and metastasis events as part of an onco-ontogenic inverse process.