Prevalence of types 16 and 33 is increased in high‐risk human papillomavirus positive women with cervical intraepithelial neoplasia grade 2 or worse

• Published in: International journal of cancer Vol. 117; no. 2; pp. 177 - 181
• Main Authors: Bulkmans, Nicole W.J., Bleeker, Maaike C.G., Berkhof, Johannes, Voorhorst, Feja J., Snijders, Peter J.F., Meijer, Chris J.L.M.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.11.2005; Wiley-Liss
• Subjects: Biological and medical sciences; cervical intraepithelial neoplasia; Cervical Intraepithelial Neoplasia - epidemiology; cervical screening; Cohort Studies; Female; Female genital diseases; Gynecology. Andrology. Obstetrics; HPV 16; HPV 33; Human papillomavirus; Human papillomavirus 16; Human papillomavirus 33; Humans; Medical sciences; Netherlands - epidemiology; Papillomaviridae - classification; Papillomaviridae - isolation & purification; Papillomavirus Infections - epidemiology; Prevalence; Tumor Virus Infections - epidemiology; Tumors; Vaginal Smears; Netherlands; Europe; Human; Premalignant lesion; Prevalence; Papovaviridae; Medical screening; Epidemiology; Female genital diseases; Infection; Papillomavirus; Virus; Human papillomavirus 16; Human papillomavirus; Cancerology; Cervical dysplasia; Viral disease; Cervical intraepithelial neoplasia; Adult; Female; HPV 33; cervical screening; HPV 16; Uterine cervix diseases; Public health
• ISSN: 0020-7136; 1097-0215
• DOI: 10.1002/ijc.21210

High‐risk human papillomavirus (hrHPV) types are causally related to cervical cancer and its high‐grade precursor lesions. The risk posed by the different hrHPV types for the development of cervical intraepithelial neoplasia grade 2 or worse (≥CIN2) needs to be established. Here, we present the hrHPV type‐distribution in relation to cytology and histology for women participating in a cervical screening program. From 44,102 women who participated in a population‐based cervical screening program in the Netherlands, 2,154 hrHPV GP5+/6+ PCR positive women were recruited to determine the distribution of 14 hrHPV types by reverse line blotting of GP5+/6+ PCR products. For each HPV type, associations with cytology and histologically confirmed ≥CIN2 were measured by odds ratios. HPV types 16 and 33 were more prevalent in women, amongst those containing a single hrHPV type, with moderate dyskaryosis or worse (>BMD) than in women with normal cytology, but only in case of underlying ≥CIN2 (OR 4.10, 95%CI 2.98–5.64 and OR 2.68, 95%CI 1.39–5.15, respectively). Similar results were obtained for women with double infections (OR 3.29, 95% CI 1.61–6.75 and OR 4.37, 95% CI 1.17–16.34). Coexisting types did not influence the prevalence of ≥CIN2 in HPV 16 or 33 positive women. The increased prevalence of type 16 and 33 in hrHPV positive women with ≥CIN2, compared to women with normal cytology, suggests that infection with these types confers an increased risk for development of ≥CIN2. Distinguishing these types may therefore have implications for future cervical screening strategies. © 2005 Wiley‐Liss, Inc.