Interactions between human norovirus and intestinal microbiota/microbes: A scoping review

• Published in: Food microbiology Vol. 119; p. 104456
• Main Authors: Yang, Yaqi, An, Ran, Lyu, Chenang, Wang, Dapeng
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.05.2024
• Subjects: burden of disease; Caliciviridae Infections; food microbiology; Gastroenteritis; Gastrointestinal Microbiome; gene expression; Human norovirus; Humans; Intestinal microbes; intestinal microorganisms; Intestines; Murine norovirus; Norovirus; Norovirus - genetics; pathogenicity; Virus-bacteria interaction; Virus-like particles; viruses; Murine norovirus; HuNoV; Human norovirus; EPS; HBGAs; LAB; Virus-like particles; VLPs; Intestinal microbes; MNV; CMVs; OMVs; Virus-bacteria interaction; AGE
• ISSN: 0740-0020; 1095-9998; 1095-9998
• DOI: 10.1016/j.fm.2023.104456

Human norovirus (HuNoV) is an important foodborne virus, which causes non-bacterial acute gastroenteritis and is associated with a high disease burden. Recently, researchers have focus on the interaction between HuNoV and intestinal microbiota/microbes and engaged in studies investigating the implications of this interaction on HuNoV infection. However, the interaction mechanism and the implication of this interaction on host remain obscure. Current scoping review aimed to systematically investigate the interaction between HuNoV and intestinal microbiota, as well as their implication on HuNoV or HuNoV related symptoms. We found that HuNoV could bind to intestinal microbes and affect the intestinal microbial composition, diversity, and microbial gene expression. In reverse, intestinal microbes could affect HuNoV infectivity, although demonstrating contradictory effects (i.e., promote or inhibit HuNoV replication). These contradictory effects existed among microbes, in part, could be attributed to the differences among microbes (histo-blood group antigens and/or other small molecule substances). Results of current scoping review could assist in the selection and isolation of potential microbial candidates to prevent and/or alleviate HuNoV related symptoms. •Human norovirus (HuNoV) infection leads to alterations in intestinal microbiota.•HuNoV infected subjects with different microbiota compositions exhibit dissimilar clinical symptoms.•Intestinal microbes exhibited contradictory effects on HuNoV infection.•Intestinal microbes could bind to HuNoV via bacterial originated substances.